中国医院用药评价与分析2016，Vol.16Issue(10)：1311-1313,1314,4.DOI:10.14009/j.issn.1672-2124.2016.10.005
替吉奥或卡培他滨联合奥沙利铂治疗晚期胃癌的疗效观察Δ
Observation on Efficacy of Tegafur Gimeracil Oteracil Potassium Capsules Combined with Oxaliplatin in Treatment of Advanced Gastric CancerΔ
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of Tegafur gimeracil oteracil potassium capsules combined with oxaliplatin in treatment of advanced gastric cancer.METHODS:90 patients with advanced gastric cancer admitted from Sept.2009 to Sept.2009 were selected to be divided into two groups via the random number table, with 45 cases in each. Two groups were given oxaliplatin 130 mg/m2 in the 1st and 8th day; and based on which the observation group were additionally treated with oral capecitabine 2 000 mg/m2 for twice in the 1st to 14th day;while the control group received Tegafur gimeracil oteracil potassium capsules 60 mg/m2 for twice in the 1st to 14th day.21d as a cycle, 3 cycles was applied at least, the total course was 6 months at most.RESULTS: The objective response rate, disease control rate, median overall survival time and progression-free survival time in observation group were respectively 48.88%(22/45), 75.55%(34/45), 12.10 months and 4.96 months, and in control group were respectively 51.11%(23/45), 73.33%(33/45), 11.21 months and 5.32 months, the difference was not statistically significant(P>0.05).The occurrence ofⅢ,Ⅳgrade adverse drug reactions in two groups were mainly hematological toxicity, gastrointestinal disorder and diarrhea and hand-foot syndrome, etc..CONCLUSIONS: Both tegafur gimeracil oteracil potassium capsules and capecitabine combined with oxaliplatin in treatment advanced gastric cancer were effective, which have high remission rate and can improve the progression-free survival time and overall survival time with high safety.关键词
胃癌/替吉奥/卡培他滨Key words
Gastric cancer/Tegafur gimeracil oteracil potassium capsules/Capecitabine分类
医药卫生引用本文复制引用
曹凤,王德林,刘承伟,杜芳,郝龙英,李伟伟,赵聪,王婧,曹玉娟..替吉奥或卡培他滨联合奥沙利铂治疗晚期胃癌的疗效观察Δ[J].中国医院用药评价与分析,2016,16(10):1311-1313,1314,4.基金项目
国家自然科学基金资助 （）
