中国医院用药评价与分析2016，Vol.16Issue(10)：1323-1325,1326,4.DOI:10.14009/j.issn.1672-2124.2016.10.009
乌司他丁对大鼠脑缺血再灌注后脑组织紧密连接蛋白1及血清神经元特异性烯醇化酶表达的影响Δ
Effects of Ulinastatin on Expression of Cerebral Cortex Zonula Occluden-1 and Neurone Specific Enolase in Rats with Cerebral Ischemia-reperfusion Injury
摘要
Abstract
OBJECTIVE:To probe into the protective effects of ulinastatin on ischemia-reperfusion injury. METHODS:72 healthy male SD rats were randomly selected to be divided into sham operation group, schemia-reperfusion injury model group and ulinastatin group, with 24 cases in each.Schemia-reperfusion injury model was established, expression changes of zonula occluden-1(ZO-1) and neurone specific enolase(NSE) in brain tissues of three groups were detected.RESULTS: Compared with schemia-reperfusion injury model group, expression of ZO-1 protein in ulinastatin group significantly increased, while NSE decreased significantly, with statistically significant difference(P<0.05).CONCLUSIONS:Ulinastatin can play a protective role in the brainm by inhibiting the increased cerebral ischemia and reperfusion brain barrier permeability, and reducing expression of NSE;and its protective blood-brain barrier may be related to upregulation expression of ZO-1 protein.关键词
乌司他丁/血脑屏障/缺血再灌注损伤Key words
Ulinastatin/Blood-brain barrier/Ischemical reperfusion injury分类
医药卫生引用本文复制引用
梁晓俊,钟志越,申捷..乌司他丁对大鼠脑缺血再灌注后脑组织紧密连接蛋白1及血清神经元特异性烯醇化酶表达的影响Δ[J].中国医院用药评价与分析,2016,16(10):1323-1325,1326,4.基金项目
上海市金山区科学技术创新基金项目 （）
