中国中西医结合外科杂志2016，Vol.22Issue(5)：424-427,4.DOI:10.3969/j.issn.1007-6948.2016.05.002
金匮肾气丸联合胰激肽原酶治疗弱精子症
Study of Jinkui Shenqi Pill combined Kallidinogenase on Treating Asthenospermia
摘要
Abstract
Objective To investigate the clinical efficacy of Jinkui Shenqi and kallidinogenase in treating asthenospermia patients and its possible mechanism. Methods According to the inclusion criteria, 75 patients with asthenospermia were randomly divided into control group (35 cases) and treatment group (40 cases). The control group was treated with oral vitamin E capsules, 100 mg, 2 times/day, while the treatment group took both taking 120u kallidinogenase, 3 times/day and Jinkui Shenqi Pill, 5 g per time, 2 times/day. In both groups, sperm concentration and superoxide dismutase were detected before and after three months of treatment respectively. And the pregnant women were observed. Results In the control group, before and after treatment, the semen volumes were (3.15 ± 1.13) mL vs (3.68 ± 1.24) mL, activity ratio of prorsad spermatozoa (26.54 ± 4.52) % vs (31.56 ± 5.46)%, seminal SOD (98.73 ± 13.81) μmol/mL vs (152.07 ± 28.65) μmol/mL. It had statistical difference between the group (P<0.05). In the treatment group, before and after treatment, the semen volumes were (3.02 ± 0.95) mL vs (4.25 ± 1.53) mL, sperm concentrations (20.59 ± 2.86) × 106/mL vs (28.97 ± 4.25) × 106/mL, sperm forward movement ratio (25.58 ± 4.36) % vs (48.76 ± 9.38) %, seminal SOD (102.95 ± 12.74) μmol/ml vs (203.43 ± 37.86) μmol/mL. It had statistical difference between the groups (P<0.05). Besides, it was obviously ameliorated compared to the control group (P<0.05). Conclusion Jinkui Shenqi Pill combined with kallidinogenase can obviously improve sperm activity rate and increase SOD in seminal plasma of asthenospermia patients. Its mechanism may involve reducing the oxidative stress injury in the environment of the sperm, and improving sperm motility.关键词
弱精子症/金匮肾气丸/胰激肽原酶/氧化应激/超氧化物歧化酶Key words
Asthenospermia/Jinkuishenqi pill/kallidinogenase/oxidative stress/superoxide dismutase分类
医药卫生引用本文复制引用
管凤刚,孙大林,金保方..金匮肾气丸联合胰激肽原酶治疗弱精子症[J].中国中西医结合外科杂志,2016,22(5):424-427,4.基金项目
国家自然科学基金（81473678）；国家自然科学青年基金 （）
