中国中西医结合外科杂志2016，Vol.22Issue(5)：435-437,438,4.DOI:10.3969/j.issn.1007-6948.2016.05.005
血清高尔基体膜蛋白73在原发性肝细胞癌早期诊断中的应用
Clinical Value of Serum Golgi Protein 73 in Early Diagnosis of Primary Hepatocellular Carcinoma
李庆芝1
作者信息
- 1. 山东省菏泽市立医院消化内科 菏泽 274000
- 折叠
摘要
Abstract
Objective To investigate the contents of serum Golgi protein 73(GP73)in patients with pri⁃mary hepatocellular carcinoma (HCC)and to discuss its clinical value in early diagnosis. Methods Six⁃ty-three patients with HCC, 58 patients wiht hepatic cirrhosis, 87 HBV carriers, 48 patients with other malig⁃nant tumors, and 48 healthy control people were involved in this study. GP73 in serum was measured by ELISA and AFP(α-fetoprotein)was measured by ADVIA Centaur XP Immunoassay System.The sensitivity and specifi⁃cation were calculated. Results The serum levels of GP73 in different ages, gender, tumor sizes and AFP con⁃centrations were not significantly different.The area of AFP, GP73 under the ROC curve in the differential diag⁃nosis of HCC were 0.758 and 0.808. The sensitivity and specificity value of GP73 were 88.6% and 92.1%, high⁃er than those of AFP. Conclusion In diagnosing HCC,the content of serum GP73 is superior to AFP. It is hopeful that serum GP73 may be proved to be an early serum tumor marker for HCC.关键词
高尔基体蛋白73/原发性肝细胞癌/早期诊断Key words
Golgi protein73/primary hepatocellular carcinoma/early diagnosis分类
医药卫生引用本文复制引用
李庆芝..血清高尔基体膜蛋白73在原发性肝细胞癌早期诊断中的应用[J].中国中西医结合外科杂志,2016,22(5):435-437,438,4.
