摘要
Abstract
Objective To investigate the value of combined detection of serum 25(OH)D and tumor mark⁃ers in the diagnosis of colorectal cancer (CRC). Methods Serum levels of 25(OH)D, CEA, and CA19-9 were detected in 150 healthy controls and 150 cases of CRC patients. Clinical data and laboratory indexes of recruit⁃ed subjects and pathological data of CRC patients were collected. Results Serum levels of 25(OH)D in pa⁃tients with CRC (33.17 ± 15.75 nmmol/L) was lower than that in healthy controls (41.18 ± 11.59 nmmol/L),P<0.01. CEA and CA19-9 in patients with CRC [3.67(2.14,7.20) ng/mL、8.10(3.10,18.90) U/mL] were higher than those in healthy control [2.26(1.75,3.09) ng/mL、4.82(2.90,7.35) U/mL],P<0.01. Serum 25 (OH) D and CEA in patients with CRC have poor consistency (Kappa=0.174, P<0.05). Serum CEA levels of CRC patients with non-ulcer, high and middle cell differentiation, clinical stage ofⅠ~Ⅱ period and without lymph node metasta⁃sis, were significantly lower than that of CRC patients with ulcer, poorly cell differentiation, the clinical stage ofⅢ~Ⅳ period and lymph node metastasis(P<0.05), but serum 25(OH)D levels in all groups showed no statisti⁃cal difference (P>0.05). Conclusion Combined detection of 25(OH)D, CEA and CA19-9 may has clinical application value for early diagnosis, recurrence, metastasis and prognosis of CRC.关键词
结直肠癌/25羟基维生素D/肿瘤标志物Key words
Colorectal Cancer/25(OH)D/Tumor markers分类
医药卫生
