中华临床免疫和变态反应杂志2016，Vol.10Issue(3)：197-201,5.DOI:10.3969/j.issn.1673-8705.2016.03.003
蜜蜂蜂毒致严重过敏反应临床特征
Clinical Characteristics of Anaphylaxis Induced by Honeybee Venom
摘要
Abstract
Objective To investigate the clinical characteristics of honeybee venom induced anaphylaxis. Methods Cases of anaphylaxis induced by honeybee sting were collected and analyzed retrospectively since 2011 to 2016 in Peking Union Medical College Hospital.The severity was classified into GradesⅠtoⅣbased on the systemic manifestations after honeybee sting.Patients'residence and exposure types were also analyzed.The role of venom allergenic components sIgE tests was evaluated preliminarily in distinguishing dual allergic reactions from cross-reactivity.Results Gender ratio among 30 cases was:12 (male) ∶18 (female) and average age was 35 years-old (27, 38).70.0%(21/30) of the patients lived in BTH ( Beijing-Tianjin-Hebei ) region; 23.3% ( 7/30 ) in urban areas whereas 76.7% ( 23/30) in rural areas.The distribution of severity of systemic reactions was GradeⅠ(6/30) , GradeⅡ(8/30), GradeⅢ(12/30) and GradeⅣ(4/30) respectively.There were three kinds of exposure types as following:natural (2/30), occupational (26/30) and iatrogenic (2/30).86.7% of the patients were beekeepers. The average od i1 ( honeybee venom ) sIgE detection results was 12.80 ( 2.80, 33.50) kUA/L among 30 patients.19 of 30 patients finished i208 ( phospholipase A2 ) , i3 ( wasp venom) and i209 ( antigen 5 ) detections.Only one patient whose i209 level was 8.03 kUA/L was confirmed as dual allergy to both honeybee and wasp venom among the 8 patients who had both positive results to both i1 and i3, the other 7 patients'i209 detection results were all less than 0.10 kUA/L.33%(10/30) of patients were attacked by large localized reactions after first sting, whereas anaphylaxis could be induced by second sting within 3 -12 months.Conclusions Occupational exposure was the most common cause of honeybee venom anaphylaxis.Allergenic components sIgE can be a useful diagnostic tool in the determination of dual venom allergic reactions.关键词
蜂毒液类/过敏反应/变应原Key words
bee venoms/anaphylaxis/allergens分类
医药卫生引用本文复制引用
关凯,李丽莎,王瑞琦,尹佳..蜜蜂蜂毒致严重过敏反应临床特征[J].中华临床免疫和变态反应杂志,2016,10(3):197-201,5.基金项目
公益性行业科研专项类（201502012）； （）
