医学分子生物学杂志2016，Vol.13Issue(6)：322-328,7.DOI:10.3870/j.issn.1672-8009.2016.06.000
CTLA4基因多态性与炎症性肠病遗传易感性相关性研究
Correlative Analysis between CTLA-4 Gene Polymorphism and Sus-ceptibility of Inflammatory Bowel Disease
摘要
Abstract
Objective To systematically evaluate the association of cytotoxic T lymphocyte-as-sociated antigen-4 ( CTLA-4 ) polymorphism with the risk of inflammatory bowel disease ( IBD ) . Methods All eligible case-control studies published up to now were identified by searching PubMed, EMbase, WanFang Data, CNKI, CBM and VIP. Two reviewers independently screened the studies according to the inclusion and exclusion criteria, extracted data and assessed methodo-logical quality of included studies. Then, the meta-analysis was performed using RevMan 5. 2 and Stata 12. 0 software. Results A total of 10 studies involving the association between CTLA-4-rs231775 or the ( AT) n repeat in the untranslated region and the susceptibility to IBD were includ-ed. This meta-analysis showed that a strong association between CTLA-4 gene polymorphism and the risk of IBD. CTLA-4-rs231775 increased the risk of Crohn’ s disease ( CD) [ AG+GG vs. AA: OR=1. 29 , 95% CI ( 1. 05 – 1. 59 ) , P =0. 02; GG vs. AA: OR =2. 14 , 95% CI ( 1. 14 –4. 04 ) , P=0. 02 ] . The risk of ulcerative colitis ( UC ) was increased 4. 85 times in people with the allele (≥118 bp) of (AT)n repeat fragments as compared with those without (P<0. 05) . The risk of CD in the former was increased 3. 82 times as compared with the latter ( P<0. 05 ) , and the risk of UC was elevated even 15. 5 times in people with the allele (122 bp) of ( AT) n repeat frag-ments as compared with those without ( P<0. 05 ) . Conclusion CTLA-4-rs231775 and the allele of ( AT) n repeat fragments may increase the risk of IBD.关键词
CTLA4基因/单核苷酸多态性/炎症性肠病Key words
CTLA-4 gene/polymorphism/inflammatory bowel disease分类
医药卫生引用本文复制引用
廖斐,马静静,胡雪,董卫国..CTLA4基因多态性与炎症性肠病遗传易感性相关性研究[J].医学分子生物学杂志,2016,13(6):322-328,7.基金项目
国家自然科学基金 （）
