郑州大学学报（医学版）2016，Vol.51Issue(6)：774-779,6.DOI:10.13705/j.issn.1671-6825.2016.06.021
维生素D受体基因rs2222570位点多态性与结核发病相关性的meta分析
Meta analysis on association between vitamin D receptor gene rs 2222570 polymorphisms and tuberculosis risk
摘要
Abstract
Aim:To determine the association of the vitamin D receptor ( VDR) gene rs2222570 polymorphisms with the risk of tuberculosis ( TB) .Methods:We searched for association studies correlating the VDR polymorphisms and TB u-sing pre-established keywords in Database system .Meta analysis was conducted with random effects model or fixed effects model to account for heterogeneity between studies .Twenty studies were included in the VDR gene rs 2222570 meta analy-sis.Data were analyzed in respect to associations between genotypes , alleles, genetic model and TB.Results:The results of meta analysis showed that the risk of TB was decreased in the F allele carriers (OR=0.84,95%CI=0.73~0.95);a-mong Henan population with dominant models , the risk of TB was lower(OR=0.74,95%CI=0.60~0.92).Conclusion:VDR gene rs2222570 polymorphisms may be associated with the risk of TB .关键词
结核病/维生素D受体基因/rs2222570/meta分析Key words
tuberculosis/vitamin D receptor gene/rs2222570/meta analysis分类
医药卫生引用本文复制引用
石洁,朱岩昆,郑丹薇,马晓光,王少华,李辉,邢进,吴彩霞..维生素D受体基因rs2222570位点多态性与结核发病相关性的meta分析[J].郑州大学学报（医学版）,2016,51(6):774-779,6.基金项目
“十二五”科技重大专项课题2014ZX10003002；河南省科技厅课题 （）
