检验医学与临床2016，Vol.13Issue(22)：3143-3145,3.DOI:10.3969/j.issn.1672-9455.2016.22.005
内脂素 rs13237989和 rs13224516基因多态性与2型糖尿病的相关性研究
Research on correlation between genetic polymorphism of visfatin rs 13237989,rs13224516 and type 2 diabetes mellitus
摘要
Abstract
Objective To explore the relationship between visfatin rs13237989 ,rs13224516 and type 2 diabetes mellitus (T2DM ) in Guangdong .Methods Totally 181 patients with newly diagnosed T 2DM in the second affiliated hospital of Guangzhou medical university from January 2013 to December 2014 were selected as the case group ,meanwhile 180 healthy people were select‐ed as the control group .The distribution frequency of C and T genotype in rs13237989 site as well as A and C genotype in the rs13224516 site were compared between the case group and the control group .In addition ,biochemical indicators ,including choles‐terol (CHOL ) ,triacylglycerol (TG) ,high density lipoprotein cholesterol (HDL‐C) and low density lipoprotein cholesterol (LDL‐C) were compared in different genotypes of rs13237989 and rs13224516 site in case group .Results The allelic genes distributions frequency of rs13237989 and rs13224516 conformed to the laws of genetic inheritance and the samples in the study were representa ‐tive .The differences of distribution frequencies of genetic polymorphism and allelic genes in the case group and control group had no statistical significance (P > 0 .05) .Logistic regression showed that genetic polymorphism were not correlated with T 2DM (P>0 .05) .TG ,CHOL ,HDL‐C and LDL‐C of different genotypes in patients with T 2DM had no statistical significance (P > 0 .05) . Conclusion There are no difference in genetic polymorphism of visfatin rs13237989 and rs13224516 between case group and control group ,and both of the two kinds of genotypes have no correlation with T 2DM in Guangdong .关键词
2 型糖尿病/内脂素/单核苷酸多态性Key words
type 2 diabetes mellitus/visfatin/single nucleotide polymorphism引用本文复制引用
区焕桃,周强,许新强,王卓,陆伟桃..内脂素 rs13237989和 rs13224516基因多态性与2型糖尿病的相关性研究[J].检验医学与临床,2016,13(22):3143-3145,3.基金项目
广东省科技计划资助项目（2012B061700044）；广东省医学科研基金资助项目（A2012256）。 （）
