检验医学与临床2016，Vol.13Issue(22)：3173-3176,4.DOI:10.3969/j.issn.1672-9455.2016.22.017
肥胖哮喘患儿血清脂肪因子 chemerin 水平改变及其临床意义研究
The clinical value of serum chemerin in fat children with asthma at acute stage
陈鑫 1牛淼1
作者信息
- 1. 中国人民解放军第二一 ○ 医院检验科，辽宁大连 116000
- 折叠
摘要
Abstract
Objective To estimate the clinical value of serum chemerin in fat children with asthma at acute stage .Methods One‐hundred fat children with asthma at acute stage and sixty healthy fat children were enrolled in this study .The levels of total oxida‐tion state (TOS) ,total anti‐oxidant state (TAS) ,oxidative stress index (OSI) and chemerin were measured on the admission day and discharge day .Results The level of TAS in asthma group were significantly lower than those in control group (P < 0 .05) , while TOS and chemerin in asthma group were significantly higher than those in control group (P< 0 .05) .The levels of TOS ,OSI and chemerin in asthma group on discharge day were significantly lower than those in admission day (P < 0 .05) .The levels of TOS ,OSI and chemerin in critical subgroup on both admission day and discharge day were significantly higher than those in control group (P< 0 .05) .ROC analysis showed that the AUC of chemerin for diagnosis of asthma was 0 .820 .Correlation analysis showed that chemerin were positively associated with acute stage of asthma (r= 0 .658 ,P< 0 .05) and severity (r = 0 .608 ,P< 0 .05) .Lo‐gistic regression showed that OSI (OR = 1 .24 ,P< 0 .05) and chemerin (OR = 1 .54 ,P< 0 .05) were independent risk factors for a‐cute stage of asthma .Conclusion Novel fatty factor ,chemerin ,may contribute to pathophysiological mechanism of asthma by medi‐ating the levels of oxidative stress ,which makes chemerin to be a marker for asthma with acute stage in fat children .关键词
哮喘/肥胖/脂肪因子/临床意义Key words
asthma/fat/chemerin/clinical value引用本文复制引用
陈鑫,牛淼..肥胖哮喘患儿血清脂肪因子 chemerin 水平改变及其临床意义研究[J].检验医学与临床,2016,13(22):3173-3176,4.
