国际眼科杂志2016，Vol.16Issue(12)：2176-2179,4.DOI:10.3980/j.issn.1672-5123.2016.12.02
严重PDR玻璃体切割术后雷珠单抗注射的效果观察
The effect of intravitreal ranibizumab after pars plana vitrectomy in severe proliferative diabetic retinopathy
陈博 1张宪 1杨华静 1陈志祺 1王帅帅 1尹铁梅 1孙旭芳1
作者信息
- 1. 430030 中国湖北省武汉市，华中科技大学同济医学院附属同济医院眼科
- 折叠
摘要
Abstract
•AIM: To observe the results of intravitreal injection ranibizumab after pars plana vitrectomy in severe proliferative diabetic retinopathy.• METHODS: In this retrospective non - comparative interventional case series, twelve patients had undergone pars plana vitrectomy with silicone oil tamponade, perfluoropropane tamponade or balanced salt solution tamponade. At the end of the surgery, ranibizumab was injected into vitreous cavity.•RESULTS: Average follows up was 2. 75mo. Twelve eyes include vitreous haemorrhage ( 1/12 ) , vitreous haemorrhage with fibrovascular proliferation ( 1/12 ) , tractional retinal detachment with vitreous haemorrhage ( 3/12 ) , tractional retinal detachment with fibrovascular proliferation ( 2/12 ) , tractional retinal detachment with vitreous haemorrhage and neovascular glaucoma ( 1/12 ) , tractional retinal detachment with vitreous haemorrhage and fibrovascular proliferation ( 2/12 ) , tractional retinal detachment with vitreous haemorrhage and fibrovascular proliferation and neovascular glaucoma ( 1/12 ) , traction-rhegmatogenous retinal detachment with vitreous haemorrhage ( 1/12 ) . Among these 12 eyes, 8/12 had silicone oil tamponade, 2/12 had perfluoropropane tamponade, and 2/12 had balanced salt solution tamponade. All the patients did not have any therapy before. The retinal attachment rate was 10/10. One patient( 1/12 ) had hyphema after surgery. Postoperative best-corrected visual acuity improved in 9 eyes ( 9/12 ) , was unchanged in one (2/12), decreased in (1/12) eyes. Eight eyes ( 8/12 ) did not have diabetic macular edema after surgery from the optical coherence tomography examination.•CONCLUSION:Intravitreal ranibizumab after pars plana vitrectomy is useful in severe proliferative diabetic retinopathy. It can improve the success rate of surgery;improve postoperative best - corrected visual acuity;minimize the frequence of diabetic macular edema;minimize the frequence of operations and postoperative complications.关键词
糖尿病视网膜病变/玻璃体切割术/雷珠单抗Key words
diabetic retinopathy/vitrectomy/ranibizumab引用本文复制引用
陈博,张宪,杨华静,陈志祺,王帅帅,尹铁梅,孙旭芳..严重PDR玻璃体切割术后雷珠单抗注射的效果观察[J].国际眼科杂志,2016,16(12):2176-2179,4.
