中国动物传染病学报Issue(5)：25-28,4.
2型和11型鸭疫里默氏菌二价灭活苗的研制
EFFICACY OF THE BIVALENT INACTIVATEDRIEMERELLA ANATIPESTIFERVACCINE CONTAINING SEROTYPES 2 AND 11
摘要
Abstract
The purpose of the present study was to develop an inactivated bivalentRiemerella anatipestifer vaccine containing serotypes 2 and 11.Riemerella anatipestifer strains RA1325 (serotype 2) andRA1229 (serotype 11) were cultured, inactivated and concentrated separately and mixed before formulation of a bivalent vaccine. To determine the immunogenicity of the vaccine, seven-day-old Muscovy ducks were subcutaneously vaccinated and then challenged with the live vaccine strains at days 7, 14, 21, 56, 63, 70 and 77 post challenge. Antibodies in serum samples were determined in ELISA every 7 days post vaccination. The results showed that the protection rate was over 80% at day 14 post challenge. The immunity duration of the vaccine was 60 days. The titers of antibodies during 14 to 63 days post vaccination were at a high level. The preliminary results indicated that this bivalent vaccine might be used to prevent serotypes 2 and 11Riemerella anatipestifer infection in ducks.关键词
鸭疫里默氏菌/2型/11型/二价灭活疫苗/保护指数Key words
Riemerella anatipestifer/serotype 2/serotype 11/bivalent inactivated vaccine/protection index分类
农业科技引用本文复制引用
程龙飞,叶贺佳,黄瑜,林群群,许利娜,施少华,陈翠腾,仇微红,万春和,陈红梅,彭春香..2型和11型鸭疫里默氏菌二价灭活苗的研制[J].中国动物传染病学报,2016,(5):25-28,4.基金项目
现代农业产业技术体系建设专项资金（CARS-43）；福建省属公益类项目 （）
