北京中医药大学学报2016，Vol.39Issue(11)：920-925,6.DOI:10.3969/j.issn.1006-2157.2016.11.007
汉代以来著名医家治疗眩晕方剂用药规律的数据挖掘研究
Ancient TCM doctors’views on treatment of vertigo since Han Dynasty:a data mining research
摘要
Abstract
Objective To study 15 famous ancient TCMdocotors’prescribing herbal medicines for treat-ment of vertigo from Han Dynasty and the following periods,so as to provide basis for clinical treatment on vertigo as well as for researching and developing new medicines for treating vertigo.Methods A total of 128 traditional Chinese medicine prescriptions were collected and input into TCMInheritance Auxiliary Platform Version 2.5.Using the method of improved mutual information entropy clustering,association rules,complex systems entropy clustering and unsupervised entropy hierarchical clustering,the pattern types,pairs of drugs (two Chinese medicines used together),triangle drugs (three Chinese medicines used together),association rules of drugs,evolution and extraction of combination of the core drugs,and prescriptions newfound were analyzed.Results The leading pattern of vertigo was hyperactivity of liver yang (frequency:30;rate:23.4%.Same below).The most commonly used herbal medicine was Fuling (49,38.3%),and the most common pair of drugs was Zhigancao-Baizhu (29,22.7%),the most com-mon triangle drugs was Zhigancao-Baizhu-Fuling (17,13.3%).The drugs combination with high corre-lation was Baizhu-Danggui→Zhigancao,with support of 10% and confidence of 0.937 5.Altogether 22 sets of triangle drugs were extracted,in which the core drugs were Renshen,Baizhu,Zhigancao,Chen-pi,Fuling,Danggui.And 11 new prescriptions were available.Conclusion For research and develop-ment of new drugs on vertigo,we should focus on the pattern of hyperactivity of liver yang;prior compati-bility rules are Baizhu,Danggui with Zhigancao and Chenpi,Baizhu with Renshen and Zhigancao,Ren-shen with Baizhu;when formulate a new prescrption,Fuling,Fushen,Zhigancao,Chenpi,Sangye,Ju-hua,Baizhu and Renshen deserve the priority.关键词
眩晕/关联规则/数据挖掘/学术思想/新药研究Key words
vertigo/association rules/data mining/academic thought/new drug research分类
医药卫生引用本文复制引用
刘旭东,何庆勇,吴海芳,钟小雪..汉代以来著名医家治疗眩晕方剂用药规律的数据挖掘研究[J].北京中医药大学学报,2016,39(11):920-925,6.基金项目
国家自然科学基金资助项目（No．81202803），中央公益性科研院所基本科研业务费专项资金资助项目 （）
