北京中医药大学学报2016，Vol.39Issue(11)：949-954,6.DOI:10.3969/j.issn.1006-2157.2016.11.012
辅料因素对炮制蒙药诃子制草乌质量的影响
Influence of Fructus Chebulae water solution on quality of Mongolian medicine Aconiti Kusnezoffii Radix Praeparata
摘要
Abstract
Objective To study the influence of different concentration of Fructus Chebulae (Hezi)water solution on the quality of Aconiti Kusnezoffii Radix Praeparata (Zhicaowu),so as to optimize the process-ing technology and to find out the principle of detoxification of Hezi in processing.Methods Taking Hezi water solution with different concentration as the excipients,pH and content of total tannins were deter-mined.Then content of six alkaloids,indicator of toxic effect,in Zhicaowu were measured by reversed-phase HPLC.Results With the increasing of the concentration of Hezi water solution,the content of to-tal tannins increased,pH decreased at first,then kept stable,and the total six alkaloids increased slowly followed by irregularity.When the content ratio of Caowu to Hezi was 2∶1,consistent with Standard of Inner Mongolia Mongolian Medicines,the total alkaloids content was least.Conclusion Concentration of Hezi water solution and storage time changed the content of alkaloids in Zhicaowu.The content ratio of Hezi to Caowu recorded in Standard ofInner Mongolia Mongolian Medicines (in 1986)was scientific and valid.关键词
诃子制草乌/炮制/辅料/生物碱含量/pH 值/鞣质Key words
Aconiti Kusnezoffii Radix prepared with Fructus Chebulae/processing/excipients/alkaloids content/pH/tannin分类
医药卫生引用本文复制引用
刘帅,李卫飞,李妍,许金凯,刘晓艳,李飞,杜红..辅料因素对炮制蒙药诃子制草乌质量的影响[J].北京中医药大学学报,2016,39(11):949-954,6.基金项目
国家自然科学基金资助项目（No．81102815），北京市自然科学基金项目（No．7162120），北京中医药大学研究生自主课题 （）
