波谱学杂志2016，Vol.33Issue(4)：627-634,8.DOI:10.11938/cjmr20160412
靶向肺癌干细胞的多肽Gd基T1型MRI探针的研究
A Gadolinium-BasedT1 MRI Probe for Detection of Lung Cancer Stem Cells
摘要
Abstract
AT1 magnetic resonance imaging (MRI) contrast agent specific to lung cancer stem cells Gd-DOTA-HCBP-1 was synthesized by solid-phase peptide synthesis technology. Its longitudinal relaxation rate (r1) was 6.15 mmol-1·L·s-1, approximately 0.6 times higher than that of the commercialT1 contrast agents Dotarem at 11.7 T.In vitro MRI experiments indicated that the detectability of the cancer stem cells could be significantly improved to about 2 000~4 000 cells per sphere by the use of the probe.关键词
磁共振成像(MRI)/多肽分子探针/肺癌干细胞/T1造影剂Key words
MRI/peptide molecular probe/lung cancer stem cells/T1 contrast agent分类
数理科学引用本文复制引用
张宏岩,李春林,英晓芳,魏建东,张海禄,邓宗武,朱毅敏,谭波..靶向肺癌干细胞的多肽Gd基T1型MRI探针的研究[J].波谱学杂志,2016,33(4):627-634,8.基金项目
国家自然科学基金资助项目(31371010) （31371010）
