波谱学杂志2016，Vol.33Issue(4)：635-645,11.DOI:10.11938/cjmr20160413
氨基酸共聚物修饰的生物相容性MRI造影剂
A Biocompatible Gadolinium-Based Amino Acid Copolymer Contrast Agent for Magnetic Resonance Imaging
摘要
Abstract
A macromolecular gadolinium complex was prepared as a magnetic resonance imaging (MRI) contrast agent. An ethlendiamine-modified aspartic acid-valine copolymer was synthesized, conjugated with DOTA, and then chelated with Gd3+ (AI-EDA-DOTA-Gd).T1-relaxivity of the agent (i.e., 12.6 mmol–1×L×s–1) was 2.2 times that of Gd-DOTA (i.e., 5.8 mmol–1×L×s–1). Hemolytic tests showed that the macromolecular contrast agent had good blood compatibility. Histological results demonstrated low toxicity of the agentin vivo. MRI experiments on rats demonstrated a prominent enhancement in liver after AI-EDA-DOTA-Gd injection, which persisted longer than that obtained by Gd-DOTA injection. The mean percentage enhancement in liver parenchyma was (55.1±5.7)% at 30~70 min after injection.关键词
MRI造影剂/弛豫效率/氨基酸共聚物/大分子配合物/生物相容性Key words
MRI contrast agent/relaxivity/amino acid copolymer/macromolecule/biocompatibility分类
数理科学引用本文复制引用
湛游洋,薛蓉,祝云龙,李晓晶,裴奉奎,冯江华..氨基酸共聚物修饰的生物相容性MRI造影剂[J].波谱学杂志,2016,33(4):635-645,11.基金项目
国家自然科学基金资助项目(21305134) （21305134）
