吉林大学学报（医学版）2016，Vol.42Issue(6)：1099-1103,5.DOI:10.13481/j.1671-587x.20160611
miR-34a在牙龈鳞状细胞癌组织中的表达及其临床意义
Expression of miRNA-34a in gingival squamous cell carcinoma tissue and its clinical significance
摘要
Abstract
Objective:To detect the expression levels of microRNA-34a (miR-34a)in gingival squamous cell carcinoma (GSCC)tissue and adjacent tissue,and to clarify its correlation with the pathological characteristics of GSCC patients, including tumor size,malignancy degree, age, gender, tumor site and lymph node metastasis. Methods:The tissue samples including 30 GSCC tissues and matched carcinoma adjacent tissues were selected.The expression levels of miR-34a in GSCC tissue and carcinoma adjacent tissue were detected by quantitative reverse transcription-PCR (qRT-PCR)method.The relationship between its expresion level and the clinicopathological characteristics of GSCC patients were analyzed.Results:Compared with carcinoma adjacent tissue,the expression level of miR-34a in GSCC tissue was significantly decreased (t=3.03,P=0.004).The expression level of miR-34a in GSCC tissue had no relationship with the age,gender,and lymph node metastasis of the patients (P>0.05),but had relationship with the tumor size and tumor malignancy degree (P<0.05 ). Conclusion:The expression level of miR-34a is down-regulated significantly in GSCC tissue.The detection of the expression level of miR-34a contributes to judge the histological subtype.关键词
小分子 RNA 34a/癌,鳞状细胞/牙龈/临床病理特征Key words
microRNA 34a/carcinoma,squamous cells/gingiva/clinicopathological characteristic分类
医药卫生引用本文复制引用
崔磊华,及昕,李明贺,韩明林,张宁,孙兰芳,韩成敏..miR-34a在牙龈鳞状细胞癌组织中的表达及其临床意义[J].吉林大学学报（医学版）,2016,42(6):1099-1103,5.基金项目
吉林省科技厅自然科学基金资助课题（20150101173JC）；吉林省卫计委青年科研项目资助课题（3P514CP23431）；吉林省科技厅自然科学基金资助课题 （）
