吉林大学学报（医学版）2016，Vol.42Issue(6)：1138-1142,5.DOI:10.13481/j.1671-587x.20160617
子宫内膜癌组织中hMOF蛋白和mRNA表达及其临床意义
Expressions of hMOF protein and mRNA in endometrial cancer tissue and their clinical significances
摘要
Abstract
Objective:To discuss the expressions of hMOF protein and mRMA in endometrial cancer tissue,and to illuminate the possible mechanism of hMOF in the occurrence and development of endometrial cancer. Methods:The PT-PCR and immunohistochemistry methods were used to detect the expressions of hMOF protein and mRNA in 38 cases of endomerial cancer tissues and 20 cases of normal endometrial tissues,and to analyze the relationship between its expression level and the clinical characteristics and prognosis of the patients with endometrial cancer.Results:The immunohistochemistry results showed that the positive expression rate of hMOF protein in endometrial cancer tissue was lower than those in normal endometrial tissue (P=0.037);the positive expression rate of hMOF protein in stage Ⅰ patients was higher than those in stage Ⅱ and Ⅲ-Ⅳ patients (χ2=6.591,P=0.037);the positive exprssion rate of hMOF protein in the patients with poor differentiation was lower than those in the patients with moderate and high differentiation (χ2=7.351,P=0.025).The RT-PCR results showed that the percentage of the patients with expression up-regulation of hMOF mRNA in endometrial carcinoma tissue was remarkly decreased compared with normal endometrial tissue (P=0.003).Conclusion:hMOF protein may participate in the occurrence and development of endometrial cancer,and hMOF protein could be a biomarker for prognosis of endometrial cancer.关键词
乙酰基转移酶类/子宫内膜肿瘤/腺癌/聚合酶链反应/免疫组织化学Key words
acetyltransferases/endometrial neoplasms/adenocarcinoma/polymerase chain reaction/immunohistochemistry分类
医药卫生引用本文复制引用
文爱平,汪海娇,金景姬,蔡勇,朱继红,谌伦华..子宫内膜癌组织中hMOF蛋白和mRNA表达及其临床意义[J].吉林大学学报（医学版）,2016,42(6):1138-1142,5.基金项目
国家自然科学基金资助课题 （）
