磁共振成像2016，Vol.7Issue(11)：819-824,6.DOI:10.12015/issn.1674-8034.2016.11.005
磁共振3D-ASL与1H-MRS对脑胶质瘤术前分级的对比研究
Comparison of 3D-ASL and1H-MRS magnetic resonance imaging techniques for the preoperative grading of brain glioma
董卫敏 1齐旭红 1康群凤 1毕冬梅 1于洋 1孟凡祺 1温智勇1
作者信息
- 1. 国家电网公司北京电力医院放射科，北京 100073
- 折叠
摘要
Abstract
AbstractObjective:To investigate the value of three-dimensional arterial spin labeling (3D-ASL) MR perfusion imaging and1H-magnetic resonance spectroscopy (1H-MRS) metabolite in grading the cerebral gliomas.Materials and Methods:3D-ASL and1H-MRS imaging of total 44 patients with pathologically- proved gliomas were retrospectively analyzed. According to the 2007 World Health Organization (WHO) standards, the patients were divided into low-grade glioma group (gradeⅠ—Ⅱ, 13 cases) and high-grade glioma group (gradeⅢ—Ⅳ, 31 cases), measuring and calculating the values or relative values of CBF and metabolites of the tumor parenchyma and corresponding contralateral tissue for statistical analysis.Results:In the 44 cases of glioma, 3D-ASL related parameters (TBFmax, rCBF1, rCBF2) and1H-MRS related parameters (rNAA, rCr, Cho/Cr, NAA/Cho) had statistically signiifcant differences in the low-grade and the high-grade glioma group (P<0.05), and1H-MRS parameters (rCho, NAA/Cr) had no statistically signiifcant differences between the two groups (P>0.05). By receiver operating characteristic curve (ROC) analysis, the AUC of TBFmax, rCBF1, rCBF2 and rNAA, rCr, Cho/Cr, NAA/Cho was larger than 0.5 in glioma grades, while the AUC of 3D-ASL was 0.923 and the AUC of1H-MRS was 0.871, both were lesser than the AUC of 3D-ASL plus1H-MRS combination (0.955). The sensitivity and speciifcity of combining <br> the two technologies in differentiating glioma grades were 87.1% and 100% respectively.Conclusions:Separately analysising 3D-ASL and1H-MRS, 3D-ASL has a higher diagnostic value. combining the two technologies, which can complement each other, has a higher diagnostic value than 3D-ASL or1H-MRS in differentiating glioma grades.关键词
神经胶质瘤/自旋标记/磁共振波谱学/肿瘤分级Key words
Glioma/Spin labels/Magnetic resonance spectroscopy/Neoplasm grading分类
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董卫敏,齐旭红,康群凤,毕冬梅,于洋,孟凡祺,温智勇..磁共振3D-ASL与1H-MRS对脑胶质瘤术前分级的对比研究[J].磁共振成像,2016,7(11):819-824,6.
