磁共振成像2016，Vol.7Issue(11)：837-841,5.DOI:10.12015/issn.1674-8034.2016.11.008
动态增强MRI对鼻咽癌放化疗疗效的预测价值
Value of dynamic contrast-enhancement MRI for the prediction of chemoradiotheray efifcacy in nasopharyngeal carcinoma
郭笑寒 1田兴仓 2李文玲 2穆丽莎 2孙凯 2蒲艳军 2朱力2
作者信息
- 1. 第四军医大学唐都医院放射科，西安 710038
- 2. 宁夏医科大学总医院放射科，银川 750004
- 折叠
摘要
Abstract
Objective:To prospectively evaluate the efficacy of pre-treatment DCE-MRI for treatment response to chemoradiotherapy (CRT) of nasopharyngeal carcinoma. Materials and Methods:Thirty-seven patients with conifrmed NPC by biopsy pathology underwent MRI plain scan and DCE-MRI before concurrent chemoradiation. Calculate the mean, maximum and minimum area of the semiquantitative parameters. Reexamined those patients with MRI during treatment (receiving dose of 56 Gy) and measure the tumor regression rate respectively. Classiifed patients into responders and nonresponders, based on RECIST 1.1.Spearman correlation analysis was examed between both pre-treatment mean, hign enhancement and low enhancement area of the semiquantitative parameters and regression rate,respectively. ROC analyses were used to determine the best model to discriminate responders from nonresponders.Results:Among all the parameters, there was a signiifcant negative correlation between tumor regression rate and maximum TTP. When use TTP<65.53s as a cutoff, we observed AUC=0.843 with sensitivity and speciifcity is 100% and 43.33% respectively in differentiating CR (n=7) from others (n=30). Conclusions:Semiquantitative parameters derive from DCE-MRI before treatment were capable to predict early treatment efficacy during concurrent chemoradiation in nasopharyngeal carcinoma, which has potential to be helpful in individualized therapy.关键词
鼻咽肿瘤/磁共振成像/化学放射疗法/方案评价Key words
Nasopharyngeal neoplasms/Magnetic resonance imaging/Chemoradiotherapy/Program evaluation分类
医药卫生引用本文复制引用
郭笑寒,田兴仓,李文玲,穆丽莎,孙凯,蒲艳军,朱力..动态增强MRI对鼻咽癌放化疗疗效的预测价值[J].磁共振成像,2016,7(11):837-841,5.
