动物医学进展2016，Vol.37Issue(11)：87-90,4.
同源异体骨髓间充质干细胞移植治疗犬急性肝功能损伤
Treatment of Acute Liver Injury in Dogs by Allogeneic Transplantation of Bone Marrow Mesenchymal Stem Cells
曾梦颖 1汪登如 2闫晓霞 1刘欢欢 1严玉霖1
作者信息
- 1. 云南农业大学动物科学技术学院，云南昆明 650201
- 2. 昆明爱美森宠物医院，云南昆明 650224
- 折叠
摘要
Abstract
This study was designed to investigate the allogeneic transplantation bone marrow mesenchymal stem cells (BMMSCs)for treatment on canine acute hepatic injury,which provided a theoretical basis and technical support for the clinical application of canine stem cell transplantation.The canine BMMSCs were transplanted to treat acute liver injury of 10 dogs by ultrasound-guided near hepatic portal in abdomen,the routine blood,the liver function and liver B ultrasound were detected after transplantation,and the simul-taneous symptoms and adverse reactions were observed.The results showed that routine blood test indexes returned to normal after 21 days transplantation,various liver function indexes were ameliorated signifi-cantly after 7 days transplantation.B ultrasound results showed that the liver tissue echoed uniformly,no obvious abnormalities after 10 days,and the spirit,strength,appetite of dogs was improved evidently after 14 days,all dogs were recovered after 21 days and no adverse reaction were observed.Compared to the conventional treatment,the results indicated that canine BMMSCs allogeneic transplantation for treatment canine acute liver injury in dogs was safe and effective and no side effects,and could enhanced life quality of dogs significantly.关键词
犬骨髓间充质干细胞/异体移植/肝功能损伤Key words
canine bone marrow mesenchymal stem cell/allogeneic transplantation/liver injury分类
农业科技引用本文复制引用
曾梦颖,汪登如,闫晓霞,刘欢欢,严玉霖..同源异体骨髓间充质干细胞移植治疗犬急性肝功能损伤[J].动物医学进展,2016,37(11):87-90,4.
