湖南中医药大学学报2016，Vol.36Issue(11)：41-45,5.DOI:10.3969/j.issn.1674-070X.2016.11.011
原发性开角型青光眼患者眼底荧光血管造影及血液流变学改变与中医证型关系的研究
Changes in the Function of Fundus Fluorescein Angiography and Hemorheology and Its Relationship with TCM Syndromes in Primary Open-Angle Glaucoma
摘要
Abstract
Objective To investigate the pathogenesis of primary open-angle glaucoma. Methods The 85 patients with open-angle glaucoma were divided into 2 groups, including the high IOP group and the normal IOP group, and their data were compared with that of 24 normal persons. The changes of fundus fluorescein angiography and hemorheology and their relationship with TCM syndromes were studied. Results Compared with the normal group, the blood viscosity and hematocrit values at VH, VM, VI shear rate in the high IOP group and the normal IOP group were highly significantly different (P<0.01). The hematocrit values were higher in all TCM syndromes of primary open-angle glaucoma than those in normal group (P<0.01). Compared with the normal group, the blood viscosity and hematocrit values were higher in the liver-Qi stagnation and the deficiency of liver and kidney groups; the hematocrit values were significantly different (P<0.05). Compared with the normal group, A-CT, A-AT, A-VT in the high IOP group and the normal IOP group were highly significantly different (P<0.01); the A-CT, A-AT, A-VT values were longer in all TCM syndromes of primary open-angle glaucoma than those in normal group; the A-CT, A-AT, A-VT values were significantly different for groups of liver qi stagnation and deficiency of liver and kidney (P<0.05). Conclusion The patients in primary open-angle glaucoma and normal tension glaucoma groups show obvious changes of aggregation of the hemorheology, and the stagnation of the blood in the patients of normal group is not obvious. For all the syndromes, the most obvious pathologic status of blood stasis occurs in the syndrome of liver-Qi stagnation, the second syndrome is the deficiency of liver and kidney, and the mildest is the group of eye phlegm flooding, the trend of the syndromes is liver-Qi stagnation> deficiency of liver and kidney> eye phlegm flooding.关键词
原发性开角型青光眼/中医证型/眼底荧光血管造影/血液流变学Key words
primary open-angle glaucoma/traditional Chinese medicine syndrome/fundus fluorescein angiography/hemorheology分类
医药卫生引用本文复制引用
姚小磊,彭俊,李建超,徐剑,曾志成,彭抿,龙达,彭清华..原发性开角型青光眼患者眼底荧光血管造影及血液流变学改变与中医证型关系的研究[J].湖南中医药大学学报,2016,36(11):41-45,5.基金项目
国家自然科学基金资助项目（81273807，81403437，81603665）；教育部博士学科点基金资助项目（20124323110006）；湖南省自然科学基金重点资助项目（11JJ2050）；湖南省教育厅科研基金重点资助项目（06A052，10A094）；湖南省研究生创新基金重点资助项目（CX2013A013）；中医诊断学国家重点学科开放基金重点项目（2014-06，2015ZYZD02）；湖南省高层次卫生人才“225”工程培养项目资助；国家中医药管理局中医眼科学重点学科建设项目；湖南省中医五官科学重点学科建设项目。 （）
