吉林大学学报（理学版）2016，Vol.54Issue(6)：1401-1404,4.DOI:10.13413/j.cnki.jdxblxb.2016.06.38
基于灰值区间的微阵列模拟数据生成算法
An Algorithm for Generation of Simulated Microarray Data Based on Grey Value Interval
摘要
Abstract
Aiming at the problem of large data acquisition and high cost of microarray chip,we proposed a new algorithm for generation of simulated microarray data based on grey value interval. The algorithm simulated differential expression of genes in microarray data by means of grey value measurement,combined with cluster analysis method to create a cluster tunnel,and then generated simulation data with similar mathematical distribution and biological significance of the original data. The algorithm was verified and analyzed by simulated data and real biological data.Experimental results show that the simulation data generated by the concept of grey value interval and the generation mechanism of cluster tunnel is effective and reliable.关键词
微阵列数据/差异表达基因/聚类分析/模拟数据/样本Key words
microarray data/differentially expressed genes/cluster analysis/simulated data/sample分类
信息技术与安全科学引用本文复制引用
夏雪飞,韩啸,兰天姝,王礼华,吴佳楠,周柚..基于灰值区间的微阵列模拟数据生成算法[J].吉林大学学报（理学版）,2016,54(6):1401-1404,4.基金项目
国家自然科学基金(批准号:61373051 （）
61175023)、教育部春晖计划项目(批准号:Z2015024)和吉林省教育厅计划项目(批准号:2016292) （批准号:Z2015024）
