中国临床保健杂志2016，Vol.19Issue(6)：595-598,4.DOI:10.3969/J.issn.1672-6790.2016.06.010
乳腺癌组织雄激素受体表达及其与启动子甲基化的关系
Relationship between androgen receptor expression and its promoter methylation in patients with breast cancer Wang Hai,Ling Yang,Sheng Guifeng,Liu
摘要
Abstract
Objective To investigate the relationship between the expression of androgen receptor (AR)and promoter methylation in patients with breast cancer.Methods AR protein expression and promoter methylation status of 38 cases with breast cancer were detected by immunohistochemistry and real-time fluorescence quantitative PCR,and the clinical pathological data were analyzed.Results There were no significant correlation between AR expression and age, lymph node metastasis,histological grade,ER and HER-2 expression in breast cancer(P >0.05).The methylation level of AR gene in AR expression negative group was significantly higher than that in the positive group(P =0.015).The age of the patients was negatively correlated with the methylation level of AR gene(r =-0.3486,P =0.0372).There were no significant correlation between lymph node metastasis,histological grade,ER and AR gene methylation (P >0.05).Conclusion The methylation level of AR gene is significantly higher in patients with negative-AR breast cancer.关键词
乳腺肿瘤/受体,雄激素/甲基化Key words
Breast neoplasms/Receptors,Androgen/Methylation分类
医药卫生引用本文复制引用
王海,凌扬,盛桂凤,刘永萍,周林艳,张亚平..乳腺癌组织雄激素受体表达及其与启动子甲基化的关系[J].中国临床保健杂志,2016,19(6):595-598,4.基金项目
江苏省科技厅临床医药专项基金（BL2013012）；常州市科技计划项目 （）
