中国临床保健杂志2016，Vol.19Issue(6)：611-614,4.DOI:10.3969/J.issn.1672-6790.2016.06.015
老年脑血管狭窄患者认知功能的改变及影响因素
The changes of cognitive function in elderly patients with cerebral vascular stenosis
王小永 1于翔 1李永强 1王军文 1任敏1
作者信息
- 1. 陕西宝鸡市中心医院神经内科，721008
- 折叠
摘要
Abstract
Objective To observed and analyze the changes of cognitive function in elderly patients with cere-bral vascular stenosis.Methods A total of 200 elderly patients with ischemic cerebral vascular disease were selected as research objects.The cerebral vascular stenosis,risk factors of cerebrovascular disease ,scores of mini-mentalstateexami-nation (MMSE)and incidence of cognitive dysfunction were observed and analyzed.Results The age,the rate of mer-ged diabetes,the rate of merged hypertension,the plasma homocysteine (Hcy),plasma fibrinogen,the serum total cho-lesterol of the patients with cerebral vascular stenosis were significantly higher than those ofthe patients without cerebral vascular stenosis (t =4.223,3.812,3.635,χ2 =33.734,9.814,all P <0.05 ).The MMSE score,immediate recall score,attention and calculationscore,delayed recall score of the patients with mild stenosis were significantly higher than those of patients with moderate stenosis or severe stenosis.The MMSE score and delayed recall score of the patients with moderate stenosis were significantly higher than those of patients with severe stenosis.The incidence of cognitive dys-function in the patients with severe stenosis was significantly higher than that in patients with moderate stenosis,and the incidence of cognitive dysfunction in patients with moderate stenosis was significantly higher than that in patients with mild stenosis (P <0.05).Logistic multivariate regression analysis showed that there were a statistical relation between age (OR =1.397),merged hypertension (OR =1.456),plasma Hcy level (OR =1.658)and degree of cerebral vascu-lar stenosis (OR =2.138)had a to cognitive dysfunction of patients (all P <0.05).Conclusions Cerebral vascular stenosis may be involved in the pathological processes of cognitive impairment,and can be used as an secondary indicati-or to predict the risk of cognitive dysfunction in the elderly patients.关键词
脑缺血/认知障碍/危险因素/老年人Key words
Brain ischemia/Cognition disorders/Risk factors/Aged分类
医药卫生引用本文复制引用
王小永,于翔,李永强,王军文,任敏..老年脑血管狭窄患者认知功能的改变及影响因素[J].中国临床保健杂志,2016,19(6):611-614,4.
