中国临床保健杂志2016，Vol.19Issue(6)：634-636,3.DOI:10.3969/J.issn.1672-6790.2016.06.022
糖尿病小鼠心肌组织中动力相关蛋白1的表达变化
Expression of Drp1 in heart of diabetic mice
荆哲 1刘峰舟 2陈永清 1刘燕 1陈冲 3景策4
作者信息
- 1. 兰州军区兰州总医院心血管内科，兰州 730050
- 2. 解放军九四一九五部队卫生队
- 3. 解放军第四五一医院门诊部
- 4. 第四军医大学西京医院内分泌科
- 折叠
摘要
Abstract
Objective To observe the expression of Drp1 in the cardial muscle tissue of diabetic mice and nor-mal mice.Methods Nine male db /db mice were randomly divided into 3 groups(db /db 6week group,db /db 12week group and db /db 18week group).Nine male normal mice were randomly divided into another 3 groups(wt 6week group, wt 12week group and wt 18week group).The expression of Drp1 was detected by real-time PCR,Western Blot and im-munohistochemical.Results Compared to the normal group,the expression of Drp1 was decreased obviously in db /db mice group,and was gradually decreased with age.Conclusions The decreased expression of Drp1 maybe is one of the possible mechanisms of diabetic cardiomyopathy.关键词
糖尿病,2型/心肌/动力蛋白质Ⅰ/线粒体,心脏/小鼠,近交DBAKey words
Diabetes mellitus,type 2/Myocardium/Dynamin I/Mitochondria,heart/Mice inbred DBA分类
医药卫生引用本文复制引用
荆哲,刘峰舟,陈永清,刘燕,陈冲,景策..糖尿病小鼠心肌组织中动力相关蛋白1的表达变化[J].中国临床保健杂志,2016,19(6):634-636,3.
