药学研究2016，Vol.35Issue(11)：621-627,7.DOI:10.13506/j.cnki.jpr.2016.11.001
两性霉素B的结构修饰研究进展
An overview of structural modifications of amphotericin B
摘要
Abstract
Amphotericin B has been the first choice of clinical drugs to treat systemic mycosis since it was launched on the market,which makes full use of its curative effects by selectively disrupting the cell membrane of fungi.But its clin-ical applications are greatly limited due to several drawbacks,such as poor solubility,low bioavailability,severe side effects,etc.Many scientists have devoted themselves to explore the mechanism of action and structural modification of am-photericin B over the years,and achieved significant results.This article briefly reviewed the progress in structural modifi-cation of amphotericin B,aiming at providing valuable information for related research.关键词
两性霉素 B/结构修饰/衍生物/作用机制Key words
Amphotericin B/Structural modification/Derivatives/Mechanism of action分类
医药卫生引用本文复制引用
吕薛,胡立宏..两性霉素B的结构修饰研究进展[J].药学研究,2016,35(11):621-627,7.基金项目
国家自然科学基金项目 （）
