山东医药2016，Vol.56Issue(43)：11-14,4.DOI:10.3969/j.issn.1002-266X.2016.43.004
酒依赖患者胼胝体纤维的磁共振弥散张量成像检查结果分析
Magnetic resonance diffusion tensor imaging of the fiber of corpus caIIosum in aIcohoI-dependent patients
摘要
Abstract
Objective To observe the changes in fiber number and structure of corpus callosum in patients with alco-hol dependence through fiber tractography of magnetic resonance diffusion tensor imaging.Methods T1 -weighted magnetic resonance imaging and diffusion tensor imaging were obtained from 48 alcohol-dependent patients (observation group)and 50 cases of age,sex,education year-matched normal controls (control group).The fiber number,fiber fractional anisotro-py (FA),and fiber apparent diffusion coefficient (ADC)of the corpus callosum between the two groups were calculated. Results The fiber number of total corpus callosum in the observation group was 2587 ±654,which was 2875 ±758 in the control group,and significant difference was found between these two groups (P <0.05).The fiber number in anterior one third of corpus callosum in the observation group was 782 ±254,which was 987 ±244 in the control group,there was sig-nificant difference between the two groups (P <0.01).The FA values of total corpus callosum in the observation group were 0.61 ±0.02,which were significantly decreased as compared with than that (0.62 ±0.02)of the control group (P <0.05).FA values of anterior one third of corpus callosum in the observation group (0.59 ±0.03)were decreased as com-pared with that (0.61 ±0.03)of the control group (P <0.01).Compared with the control group [(0.91 ±0.07)×10 -3 mm2 /s],the ADC values of total corpus callosum in the observation group [(0.94 ±0.07) ×10 -3 mm2 /s]were signifi-cantly increased (P <0.05).The ADC values of anterior one third of corpus callosum in the observation group [(0.94 ± 0.06) ×10 -3 mm2 /s]were increased as compared with that [(0.87 ±0.08) ×10 -3 mm2 /s]of the control group (P <0.01).Conclusion Fiber number and structure of the corpus callosum is abnormal in alcohol-dependent patients and this anomaly in the anterior one third of corpus callosum is more obvious.关键词
酒依赖/胼胝体/胼胝体纤维/磁共振成像/弥散张量成像/纤维跟踪技术Key words
alcohol dependence/corpus callosum/fiber of corpus callosum/magnetic resonance imaging/diffusion tensor imaging/fiber tractography分类
医药卫生引用本文复制引用
洪珊珊,赵中,韩伯军,王庆广,姜歧涛,郑勇强,刘定华..酒依赖患者胼胝体纤维的磁共振弥散张量成像检查结果分析[J].山东医药,2016,56(43):11-14,4.基金项目
江苏省苏州市科技发展计划项目（SYS201426）。 （）
