陕西医学杂志2016，Vol.45Issue(12)：1571-1573,3.DOI:10.3969/j.issn.1000-7377.2016.12.001
瘦素受体基因多态性与胃癌易感性研究
The relationship of leptin receptor gene polymorphisms with the susceptibility of gastric cancer
摘要
Abstract
Objective:To analyze the relationship between the leptin receptor (LEPR) gene polymor‐phisms (rs1137100 and rs1137101) with gastric cancer (GC) susceptibility .Methods :Polymerase chain reaction‐re‐striction fragment length polymorphism (PCR‐RFLP) was utilized to analyze the polymorphisms of rs1137100 and rs1137101 in 89 GC patients and 97 healthy controls .Enzyme‐linked immunosorbent assay (ELISA) was used to de‐tecte the leptin levels in blood .Results :AA genotype and A allele of LEPR rs1137100 were significantly decreased the GC risk (P=0 .036 ,OR=0 .259 ,95% CI=0 .068‐0 .987 ;P=0 .008 ,OR=0 .493 ,95% CI=0 .291‐0 .833) .No obvious correlation have existed between LEPR rs1137101 AA and GA genotypes and the risk of GC . But , rs1137101 A allele might reduce the GC risk (P=0 .006 ,OR=0 .446 ,95% CI=0 .248‐0 .802) .The serum leptin level in GC group was higher than that in the controls (P<0 .05) .Conclusion :The leptin level and LEPR gene pol‐ymorphisms (rs1137100 and rs1137101) is highly correlated with susceptibility of GC ,A allele of rs1137100 and A allele of rs1137101 might decrease the GC risk .关键词
胃肿瘤/瘦素/基因多态性Key words
Stomachneoplas/ms Leptin/Gene polymorphism分类
医药卫生引用本文复制引用
凌伟,于红刚,张海菊..瘦素受体基因多态性与胃癌易感性研究[J].陕西医学杂志,2016,45(12):1571-1573,3.基金项目
国家自然科学基金 （）
