陕西科技大学学报（自然科学版）2016，Vol.34Issue(6)：145-153,9.
靛红母核双螺环化合物的合成及抗肿瘤活性研究
Synthesis and antitumor activity evaluation of bis-spiro isatin derivatives
摘要
Abstract
To discover novel compounds with better antitumor activities and less toxicities ,a series of bis‐spiro isatin derivatives which had not been reported before were synthesized u‐sing isatin and its derivatives ,pulegone and sarcosine as raw materials .T he structure of the synthesized compounds were characterized by 1 H NMR ,13C NMR and HRMS .Additionally , the cytotoxicity of the synthesized compounds on human hepatocarcinoma cells (HepG2) , human lung cancer cells (A‐549) and human colon cancer cells (HCT‐8) have also been de‐tected by MTT method .The results revealed that these compounds have different inhibition on different cell lines to a different degree ,specifically ,compound 2 and 3 are worth further studying owing to their satisfactory activities .关键词
靛红/多组分反应/双螺环化合物/抗肿瘤/药物合成Key words
isatin/multi-component reaction/bis-spiro compound/antitumor activity/drug synthesis分类
医药卫生引用本文复制引用
梁承远,宋慧慧,王兰,丁顺军,孙涵,裴少萌..靛红母核双螺环化合物的合成及抗肿瘤活性研究[J].陕西科技大学学报（自然科学版）,2016,34(6):145-153,9.基金项目
国家自然科学基金项目（81602967）；中国博士后科学基金项目（2016M592898XB）；陕西省科技厅自然科学基金项目（2014JQ4154）；陕西省教育厅专项科研计划项目（15JK1076）；陕西省人力资源与社会保障厅博士后基金资助项目（2015）；国家级大学生创新创业训练计划项目 （）
