中国组织工程研究2016，Vol.20Issue(46)：6963-6969,7.DOI:10.3969/j.issn.2095-4344.2016.46.017
成骨细胞、破骨细胞与酒精性股骨头坏死的关联性：预防与靶向治疗的新思路
Correlation of osteoblasts and osteoclasts with alcohol-induced femoral head necrosis:a new strategy of prevention and target therapy
摘要
Abstract
BACKGROUND:Alcohol-induced femoral head necrosis is a bone metabolism disease that involves a series of alcoholism-induced pathological changes, including degeneration, necrosis and deposition of adipocytes and osteoporosis, and trabecular col apse in the subchondral bone trabeculae of the femoral head. OBJECTIVE:To introduce the correlation of osteoblasts and osteoclasts with alcohol-induced femoral head necrosis. METHODS:The first author searched relative articles in PubMed and CNKI databases published before May 2016 using the keywords of“osteoblast, osteoclast, alcohol-induced ONFH, bone metabolism”in English and Chinese, respectively. 133 literatures were retrieved and 38 literatures were in accordance with the inclusion criteria. RESULTS AND CONCLUSION:During the process of bone metabolism, osteoblasts and osteoclasts exhibit interaction in term of cel number and viability. In-depth study on osteoblasts, osteoclasts and their interaction cannot only give insight into the pathogenesis and repair of alcohol-induced femoral head necrosis, but also provide new ideas and strategies for prevention and target treatment of bone metabolic diseases.关键词
组织构建/骨组织工程/成骨细胞/破骨细胞/酒精性股骨头坏死/骨代谢/国家自然科学基金分类
医药卫生引用本文复制引用
陈俊宇,王建忠..成骨细胞、破骨细胞与酒精性股骨头坏死的关联性：预防与靶向治疗的新思路[J].中国组织工程研究,2016,20(46):6963-6969,7.基金项目
国家自然科学基金(81160228)，课题名OPG/RANKL/RANK基因多态性与蒙汉两族人群激素性骨坏死和酒精性骨坏死的关联性及淫羊藿提取物个体化防治研究@@@@the National Natural Science Foundation of China, No.81160228 （81160228）
