现代医药卫生2016，Vol.32Issue(22)：3429-3431,3.DOI:10.3969/j.issn.1009-5519.2016.22.004
他汀类药物对冠心病患者超敏C反应蛋白及血脂的影响
Effects of statins on hs-CRP and serum lipids in patients with coronary heart disease
摘要
Abstract
Objective To investigate the effect of statins on high sensitive C reactive protein (hs-CRP) and blood lipids in the patients with coronary heart disease(CHD). Methods A total of 1 340 patients with suspected CHD by coronary arterial angiography and PCI in necessity in our hospital from January to December 2015 were selected and divided into the taking statins group(236 cases) and the non-taking statins group(1 104 cases)according to the clinical disease history and angiography results;then the latter was further divided into the control group(358 cases,normal coronary artery),coronary atherosclerosis group(238 cases,coronary arterial stenosis degree<50%) and stable angina group(172 cases,coronary arterial stenosis degree 50%~75%without giving PCI) and unstable angina conducting PCI group(110 cases,coronary arterial stenosis degree 50%~75%with PCI) and unstable angina group(225 cases,coronary arterial stenosis degree>75%with PCI). The levels of serum hs-CRP,LDL-C, HDL-C,TC and TG were compared among different groups. Results The levels of hs-CRP,LDL-C,HDL-C,TC and TG in the taking statins group were significantly lower than those in the non-taking statins group,moreover the hs-CRP level was significantly lower than that in the stable angina group,stable angina-PCI group and unstable angina group,the differences were statistically significant(P<0.05),but the differences had no statistical difference compared with the control group and coronary atherosclerosis group(P>0.05);the LDL-C and TC levels in the taking statins group were significantly lower than those in the non-taking statins subgroups,while the HDL-C level was significantly lower than that in the control group and coronary atherosclerosis group ,the TG level was significantly lower than that in the control group ,coronary atherosclerosis group and unstable angina group ,the differ-ences were statistically significant(P<0.05). Conclusion Statins not only reduce the level of LDL-C significantly,but also signif-icantly reduce the level of hs-CRP,thus alleviate the inflammatory reaction.关键词
冠心病/脂类/血液/超敏C反应蛋白/他汀类药物Key words
Coronary disease/Lipids/blood/High sensitive C-reactive protein/Statins引用本文复制引用
胡圣大,钱璐,陈弹,曹明强,李晓波,朱莎莎,周亚峰..他汀类药物对冠心病患者超敏C反应蛋白及血脂的影响[J].现代医药卫生,2016,32(22):3429-3431,3.基金项目
江苏省苏州市科技项目（SYSD2015068）。 （）
