现代医药卫生2016，Vol.32Issue(22)：3443-3445,3.DOI:10.3969/j.issn.1009-5519.2016.22.009
原发免疫性血小板减少症患者Th1/Th2水平及临床意义
Th1/Th2 level and clinical significance in patients with primary immune thrombocytopenia
费晓莉 1练颖 1官晓红 1雷丽华 1陶黎 1何东 1林娟 1任倩1
作者信息
- 1. 成都市第一人民医院血液内科，四川610041
- 折叠
摘要
Abstract
Objective To investigate the change of serum Th1 (IL-2,IL-3,TNF-α) and Th2 (IL-6,IL-10,IL-13) levels and its clinical significance in the patients with primary immune thrombocytopenia (ITP). Methods The levels of serum IL-2, IL-3,TNF-α,IL-6,IL-10 and IL-13 were detected by double sandwich enzyme-linked immunoabsorbent assay(ELISA) before and after treatment in 42 cases of ITP(research group) and 20 healthy volunteers(control group)in our hospital from September 2011 to March 2016. Results The Th1 level before treatment in the research group was significantly higher than that in the control group,while the Th2 level was significantly lower than that in the control group,the Th1 level after treatment in the research group was significantly lower than before treatment,while the Th2 level was significantly higher than before the treatment,the difference was statistically significant(P<0.05). Conclusion Th1/Th2 imbalance is associated with the onset of ITP and the glucocorticoid therapy can adjust the imbalance status of Th1/Th2.关键词
免疫/血小板减少/Th1细胞/Th2细胞/细胞因子类Key words
Immunity/Thrombocytopenia/Th1 cells/Th2 cells/Cytokines引用本文复制引用
费晓莉,练颖,官晓红,雷丽华,陶黎,何东,林娟,任倩..原发免疫性血小板减少症患者Th1/Th2水平及临床意义[J].现代医药卫生,2016,32(22):3443-3445,3.
