原子与分子物理学报2016，Vol.33Issue(6)：1082-1086,5.DOI:10.3969/j.issn.1000-0364.2016.12.021
组蛋白H1序列固有无序特性分析
Analysis of intrinsically disordered characteristics for histone H1
摘要
Abstract
Histone H1 is important both for maintenance of higher-order chromatin structure and for the regula-tion of gene expression. In this work, in order to reveal the biological mechanism of histone H1 in the formation of chromatin structure, the probability of amino acid, amino acid sequence complexity and the analyzes about junction of three domains are adopted to systematic comprehensive study the sequence features of the three do-mains(C-terminal domain (CTD), N-terminal domain(NTD) and Globular domain (GD)) of Histone H1, and the ordered / disordered protein region of each sequence is predicted. The results indicate that the amino acid sequence of the globular domain ( GD) is highly conserved, NTD is rich in hydrophobic amino acids, and the CTD is rich in basic amino acids, lysine, serine, proline and alanine. Further studies show that CTD and NTD have intrinsically disorder characteristics, so the two regions have a large flexible structure, which can pro-mote them to preform the important biological functions in the formation of the chromatin.关键词
组蛋白H1/固有无序蛋白/序列分析Key words
Histone H1/Intrinsically disordered protain/Analysis of sequence分类
生物科学引用本文复制引用
王春玲,于家峰,王红梅,王吉华..组蛋白H1序列固有无序特性分析[J].原子与分子物理学报,2016,33(6):1082-1086,5.基金项目
国家自然科学基金项目(61302186,61271378) （61302186,61271378）
山东省自然科学基金项目(ZR2010CQ041) （ZR2010CQ041）
