中国全科医学2016，Vol.19Issue(34)：4183-4186,4195,5.DOI:10.3969/j.issn.1007-9572.2016.34.007
2型糖尿病合并高血压脑损害代谢物改变研究
Metabolites Alterations of Brain Damage in Type 2 Diabetic Patients Combined With Hypertension
摘要
Abstract
Objective To investigate the metabolites alterations of brain damage in type 2 diabetic patients combined with hypertension. Methods Thirty - three type 2 diabetic patients combined with hypertension,who received treatment in the outpatient of or hospitalized in the Second Affiliated Hospital of Shantou University Medical College from April 2013 to November 2014,were selected as the patients group,and 30 healthy volunteers whose gender,age,and educational years were matched with those of the patients group were enrolled as the control group at the same period. The US GE signa HDXT - Speed(1. 5T superconducting magnetic resonance imager)was used in the study. The scanning results of two - dimensional H magnetic resonance spectrum was shown as follow,the voxel was located in the semiovale center,the volume of interest was 7 cm í 10 cmí 2 cm,TR 1 500 ms,and TE 35 ms. The SAGE software was used to measure the specific value of bilateral frontal lobe gray matter and left parietal lobe white matter,including N - acetylaspartate( NAA) / creatine( Cr)and Choline( Cho) / Cr. Statistical analysis were performed with SPSS 17. 0. Results There were significant differences in NAA/ Cr and Cho/ Cr in left frontal lobe and NAA/ Cr and Cho/ Cr in right frontal lobe and NAA/ Cr in the left parietal lobe between the two groups (P < 0. 05),while there were no significant differences in Cho/ Cr in left parietal lobe and NAA/ Cr and Cho/ Cr in right parietal lobe(P > 0. 05). The NAA/ Cr between left frontal lobe and left parietal lobe(t = 0. 77,P = 0. 45);between right frontal lobe and right parietal lobe( t = - 0. 81,P = 0. 43);between left frontal lobe and right frontal lobe( t = - 0. 66,P = 0. 51);between left parietal lobe and right parietal lobe(t = - 0. 45,P = 0. 65)in the control group was not significantly different;and Cho/ Cr between left frontal lobe and left parietal lobe(t = 0. 49,P = 0. 63);between right frontal lobe and right parietal lobe(t= 0. 53,P = 0. 59);between left frontal lobe and right frontal lobe(t = - 0. 96,P = 0. 35);and between left parietal lobe and right parietal lobe(t = - 0. 79,P = 0. 93)was also not significantly different. The NAA/ Cr between left frontal lobe and left parietal lobe(t = 5. 40,P < 0. 01);between right frontal lobe and right parietal lobe(t = - 5. 86,P < 0. 01);between left frontal lobe and right frontal lobe(t = 3. 14,P = 0. 01);and between left parietal lobe and right parietal lobe( t = 2. 74,P= 0. 01)in the patients group was significantly different;there were no significant differences in Cho/ Cr between left frontal lobe and left parietal lobe(t = - 0. 78,P = 0. 94),between left frontal lobe and right frontal lobe(t = - 0. 46,P = 0. 65),and between left parietal lobe and right parietal lobe( t = - 0. 90,P = 0. 38),while there were significant differences in Cho/ Cr between right frontal lobe and right parietal lobe(t = - 2. 93,P = 0. 04). Conclusion Brain damage caused by type 2 diabetic hypertension presents progressivity,and the metabolic dysfunction has occurred both in bilateral frontal lobe gray matter and left parietal lobe white matter. Metabolic alterations are mainly manifested by decreasing NAA/ Cr and increasing Cho/ Cr,clearer frontal lobe gray matter compared with parietal lobe white matter and the left side is clearer than the right side.关键词
糖尿病,2 型/高血压/脑损害/代谢物Key words
Diabetes mellitus,type 2/Hypertension/Brain damage/Metabolites分类
医药卫生引用本文复制引用
林小荣,曹震,何戎,张颖,肖叶玉..2型糖尿病合并高血压脑损害代谢物改变研究[J].中国全科医学,2016,19(34):4183-4186,4195,5.基金项目
国家自然科学基金资助项目（81371612）；广东省自然科学基金资助项目（S2013010013867）；广东省医学科研项目 （）
