摘要
Abstract
Objective To investigate the correlation of NT-proBNP and central aortic pressure(CAP)levels with the severity of coronary artery disease. Methods One hundred and fifty patients undergoing coronary angiography in Department of Cardiology,the Second Affiliated Hospital of Baotou Medical College from December 2012 to December 2014 were selected as the subjects. In accordance with the SYNTAX scores,they were assigned to normal coronary artery group(0 point,n = 50)and coronary lesions group(≥1 point,n = 100),and the coronary lesions group was further divided into low - risk subgroup(1 ~22 points,n = 40),medium - risk subgroup(23 ~ 32 points,n = 35)and high - risk subgroup(≥33 points,n = 25). The general information was collected,including gender,age,BMI,blood pressure,blood glucose,blood lipids and so on. Plasma NT-proBNP level was measured by American roche 2010 electrochemiluminescence immunoassay analyzer. CAP was measured by Japan's Omron's non - invasive radial artery pulse wave detection device(HEM9000AI). Results Compared normal coronary group with low - risk subgroup,medium - risk subgroup and high - risk subgroup,there was statistically significant difference in terms of age,BMI,systolic blood pressure( SBP),fasting plasma glucose( FPG),total cholesterol( TC),triglyceride (TG)and low density lipoprotein cholesterol(LDL-C)(P < 0. 05)but not in sex,diastolic blood pressure(DBP)and high density lipoprotein cholesterol(HDL-C)(P > 0. 05),and significant difference was found in terms of the level of NT-proBNP and CSP between the groups( P < 0. 05),but not in the level of CDP( P > 0. 05). The level of NT-proBNP had a linear positive correlation with the SYNTAX scores of coronary artery disease(r = 0. 870,P < 0. 001). And it showed a linear positive correlation statistically between the level of CSP and the SYNTAX scores of coronary artery disease( r = 0. 743,P < 0. 001). Conclusion Both NT-proBNP and CSP levels are positively correlated with coronary artery disease. And with the elevation of NT-proBNP and CSP levels,the severity of coronary artery disease increases.关键词
N末端B型利钠肽原/中心动脉压/冠状动脉疾病Key words
N - terminal pro - brain natriuretic peptide/Central aortic pressure/Coronary artery disease分类
医药卫生
