中国比较医学杂志2016，Vol.26Issue(11)：6-10,5.DOI:10.3969/j.issn.1671-7856.2016.11.002
presenilin－1／presenilin－2双基因敲除小鼠的寿命观察
Investigation on life span of presenilin-1/presenilin-2 conditional double knockout mice
摘要
Abstract
Objective To analyze the survival curves of presenilin-1/presenilin-2 conditional double knockout mice ( dKO mice) , and provide a reference for further breeding of this strain of mice and studying the pathogenesis of Alzheimer’s disease (AD).Methods dKO mice (50 females and 30 males) and wild-type controls (20 females and 20 males) were included in this study .The survival of all the mice was observed under the same condition of feeding and nutrition for two years .Life span of each mouse was calculated , survival curves were drawn , and their survival was analyzed.Results With the passing of time, the survival probability was decreased in dKO mice .The survival probabilities of female and male dKO mice were significantly worse than that of wild-type controls , respectively ( P <0.001, P<0.001;P<0.001, P<0.001).No significant difference was observed between the males and females of dKO mice.Conclusions Double knockout presenilin-1 and presenilin-2 genes may shorten the life span of mice , but there is no significant gender difference between the males and females of dKO mice .关键词
dKO mice/条件性基因敲除/小鼠/寿命Key words
dKO mice/Conditional knockout/Mice/Life span分类
医药卫生引用本文复制引用
唐红,唐晓琴,邓飞,李昕,陈波,唐明希,阮思蓓..presenilin－1／presenilin－2双基因敲除小鼠的寿命观察[J].中国比较医学杂志,2016,26(11):6-10,5.基金项目
四川省科技厅科技支撑计划（2012SZ0172）；四川省教育厅重点项目（16ZA0196）；西南医科大学－泸州市科技局联合资助项目（2015LZCYD－S06（6／11））；西南医科大学重点项目（2015－YJ002）；西南医科大学附属医院科研项目（15056，15087）。 （）
