中国比较医学杂志2016，Vol.26Issue(11)：18-23,6.DOI:10.3969/j.issn.1671-7856.2016.11.004
不同时长的束缚应激致雌雄大鼠的抑郁样行为改变
Depressive-like behavior of male and female rats induced by restraint stress with different restraint duration
摘要
Abstract
Objective To investigate the effects of chronic restraint stress on the depressive-like behavior of male and female SD rats with different restraint duration .Methods Sprague-Dawley rats (male and female) were subjected to restraint stress 10 h/14 h daily for 28 days.After that, sucrose preference test, open-field test, novel object test, were performed for all the rats to observe the effects of different restraint duration of chronic restraint stress on the depressive -like behaviors in male and female SD rats .Results For the 14 h/28 d CRS group , including male and female rats , the movement time and central activity time were reduced , sugar consumption index were decreased , novelty exploration time and frequency were reduced , latency were increased , numbers of nose pokes were reduced , and these results were significantly different compared with the control group .There were individual indicators that showed significantly difference for all the above-mentioned behavioral tests of the 10h/28 d CRS group.14h/28 d CRS male group in syrup consumption index decreased significantly , the corresponding female rats did not significantly reduce .10h/28 d CRS male group in the central motion time less than that of the control group , and latency was prolonged and exploration time was shortened , while the corresponding female rats had no significant difference .Conclusion 14 h/28 d CRS rats in the sucrose preference test, open-field test, novel object test were exhibited depressive-like behavior, but 10 h/28 d CRS male rats showed a trend of depressive-like behavior .Chronic restraint stress was more likely to lead to depressive-like behavior in male rats .关键词
慢性束缚应激/抑郁样行为/束缚时长/Sprague-Dawley大鼠Key words
Chronic restraint stress/Depressive-like behavior/Restraint duration/Sprague-Dawley rats分类
医药卫生引用本文复制引用
张北月,卢聪,董黎明,徐攀,何怡然,石晋丽,刘新民..不同时长的束缚应激致雌雄大鼠的抑郁样行为改变[J].中国比较医学杂志,2016,26(11):18-23,6.基金项目
全军医学科技“十二五”科研项目（ BWS11J052），新疆科技厅支疆项目（201491174）科技部国际科技合作专项（2011DFA32730）。 （）
