中国药房2016，Vol.27Issue(33)：4624-4626,4627,4.DOI:10.6039/j.issn.1001-0408.2016.33.06
比索洛尔对急性冠脉综合征患者急诊PCI术后QRS-T夹角的影响Δ
Effects of Bisoprolol on the QRS-T Angle in ACS Patients after Emergency PCI
摘要
Abstract
OBJECTIVE:To investigate the effects of bisoprolol on the QRS-T angle in ACS patients after emergency PCI. METHODS:100 ACS patients who took PCI were randomly divided into conventional group(50 cases)and bisoprolol group(50 cases),and other 50 coronary stenosis<50% were selected as control group. Patients in conventional group received Aspirin enter-ic-coated tablet 300 mg 30 min before PCI,orally,once a day+Clopidogrel bisulfate tablet 600 mg,orally,once a day,100 mg as-pirin was given in the night after PCI,orally,once a day+clopidogrel 75 mg,orally,once a day+Atorvastatin calcium tablet 20 mg,orally,once a day,and other conventional treatment. Bisoprolol group was additionally given Bisoprolol fumarate tablet 5 mg,orally,once a day. Control group received Aspirin enteric-coated tablet+Clopidogrel bisulfate tablet+Atorvastatin calcium tablet (the same dosage and usage as conventional group). All patients were treated for 12 months. The frontal QRS-T angle before and af-ter operation,Gensini score in all groups the incidence of MACE in 1-year was followed-up. RESULTS:After operation,QRS-T angle in bisoprolol group was significantly lower than before and conventional group,but higher than control group,with statistical significances(P<0.05),there was no significant difference in conventional group before and after operation(P>0.05),so as the Gensini score in 2 groups(P>0.05). The incidence of MACE in bisoprolol group was significantly lower than conventional group, with statistical significance (P<0.05). The QRS-T angle in bisoprolol group(preoperative-postoperative) negatively correlated with the incidence of MACE(r=-0.339,P=0.057). MACE risk decreased 8% if frontal QRS-T angle increased 1° in bisoprolol group (P=0.041),MACE risk increased 32% if Gensini increased 1 score(P=0.035). CONCLUSIONS:Based on conventional treatment,early use of bisoprolol can reduce the QRS-T angle and the MACE risk,and the decrease degree of frontal QRS-T angle is correlated with the incidence of MACE.关键词
比索洛尔/急性冠脉综合征/经皮冠状动脉介入术/QRS-T夹角Key words
Bisoprolol/ACS/PCI/QRS-T angle分类
医药卫生引用本文复制引用
叶沃若,王俊,刘书宇..比索洛尔对急性冠脉综合征患者急诊PCI术后QRS-T夹角的影响Δ[J].中国药房,2016,27(33):4624-4626,4627,4.基金项目
中国博士后科学基金面上资助项目（No.2015M582901）；江苏省自然科学基金资助项目（No.BK20140733）；江苏省博士后科研资助计划项目 （）
