中国药房2016，Vol.27Issue(33)：4638-4640,3.DOI:10.6039/j.issn.1001-0408.2016.33.10
长春西汀治疗急性冠脉综合征合并高血压的临床观察
Clinical Observation of Vinpocetine in the Treatment of Acute Coronary Syndrome with Hypertension
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of vinpocetine in the treatment of acute coronary syndrome(ACS) with hypertension. METHODS:90 patients with ACS and hypertension were randomly divided into control group (45 cases) and observation group(45 cases). Control group received Atorvastatin calcium tablet 20 mg,orally,once a day+Clopidogrel hydrogen sulfate tablet 75 mg,orally,once a day+Levamlodipine besylate tablet 2.5 mg,orally,once a day+Isosorbide mononitrate sus-tained-release tablet 40 mg,orally,once a day. Observation group was additionally given Vinpocetine injection 30 mg,adding into 0.9% Sodium chloride injection or 5% Glucose injection 250 ml by intravenous infusion,once a day. The 2 groups were treated for 14 d. The clinical efficacy,systolic blood pressure(SBP),diastolic blood pressure(DBP),attack frequency,duration,inter-val time of the attack,ST segment down,blood viscosity,D-dimer,platelet aggregation rate,fibrinogen levels before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,with statistical significance (P<0.05). Before treatment,there were no signifi-cant differences in SBP,DBP,attack frequency,duration,interval time of the attack,ST segment down,blood viscosity,D-di-mer,platelet aggregation rate,fibrinogen levels in 2 groups(P>0.05). After treatment,SBP and DBP in 2 groups were significant-ly lower than before,with statistical significance(P<0.05),while there was no significant difference in 2 groups(P>0.05). At-tack frequency,duration,ST segment down,blood viscosity,D-dimer,platelet aggregation rate,fibrinogen levels in 2 groups were significantly lower than before,and observation group was lower than control group,interval time of the attack in 2 groups was significantly long than before,and observation group was longer than control group,with statistical significances (P<0.05). And there was no significant difference in the incidence of adverse reactions in 2 groups (P>0.05). CONCLUSIONS:Based on the conventional treatment,both efficacy and safety of vinpocetine in the treatment of ACS with hypertension are good.关键词
长春西汀/急性冠脉综合征/高血压/疗效/安全性Key words
Vinpocetine injection/Acute coronary syndrome/Hypertension/Efficacy/Safety分类
医药卫生引用本文复制引用
魏国政,邓长金..长春西汀治疗急性冠脉综合征合并高血压的临床观察[J].中国药房,2016,27(33):4638-4640,3.基金项目
荆门市科技计划项目 （）
