摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of quetiapine combined with lithium carbonate in the treatment of bipolar disorder manic episode. METHODS:110 patients with bipolar disorder manic episode were randomly divided into control group (55 cases) and observation group (55 cases). All patients stopped antipsychotics for 7 d. After the elution period,control group received Lithium carbonate tablet 0.25 g after a meal,twice-3 times a day,for 3 d,then increased to 1-1.5 g,for twice- 3 times,after a meal. Observation group was additionally given Quetiapine fumarate tablet 0.05 g in the first day,0.1 g in the second day,0.2 g in the third day,0.3 g in the fourth day,twice a day,then changed to 0.4-0.6 g,for twice-3 times. The 2 groups were treated for 12 weeks. Clinical efficacy,mania scale(BRMS)score,positive and negative symptoms scale(PANSS)score,cogni-tive functions score before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the incidence of adverse reactions was signifi-cantly lower than control group,with statistical significance (P<0.05). Before treatment,there were no significant differences in BRMS score,PANSS score and cognitive functions in 2 groups (P>0.05). After treatment,BRMS score and PANSS score in 2 groups were significantly lower than before,and observation group was lower than control group,cognitive functions were signifi-cantly higher than before,and observation group was higher than control group,with statistical significances(P<0.05). CONCLU-SIONS:Both efficacy and safety of quetiapine combined with lithium carbonate are superior to lithium carbonate alone in the treat-ment of bipolar disorder manic episode,and it can significantly improve patients’cognitive functions.关键词
双相障碍/躁狂发作/喹硫平/碳酸锂/认知功能/疗效/安全性Key words
Bipolar disorder/Manic episode/Quetiapine/Lithium carbonate/Cognitive function/Efficacy/Safety分类
医药卫生
