中国药房2016，Vol.27Issue(33)：4707-4709,3.DOI:10.6039/j.issn.1001-0408.2016.33.33
青连宁心胶囊的质量标准研究
Study on the Quality Standard of Qinglian Ningxin Capsule
摘要
Abstract
OBJECTIVE:To establish the quality standard of Qinglian ningxin capsule. METHODS:TLC was adopted for the qualitative identification of Coptis chinensis and Artemisia carvifolia. HPLC was used for the content determination of artemisinin:column was Diamonsil C18 with mobile phase of methanol-phosphate buffer solution(45∶55,V/V)at a flow rate of 1.0 ml/min,de-tection wavelength was 260 nm,column temperature was 30 ℃,and injection volume was 10 μl. RESULTS:The TLC spots of C. chinensis and A. carvifolia were clear and well separated,negative control without interference. The linear range of artemisinin was 5.62-56.2 μg/ml(r=0.999 4);RSDs of precision, stability and reproducibility tests were lower than 1.0%;recovery was 97.46%-99.72%(RSD=0.75%,n=6). CONCLUSIONS:The satandard can be used for the quality control of Qinglian ningxin capsule.关键词
青连宁心胶囊/青蒿素/高效液相色谱法/薄层色谱法/质量标准Key words
Qinglian ningxin capsule/Artemisinin/HPLC/TLC/Quality standard分类
医药卫生引用本文复制引用
司席席,孙洪胜,曹广尚,陈倩倩,刘丹..青连宁心胶囊的质量标准研究[J].中国药房,2016,27(33):4707-4709,3.基金项目
山东省重点研发计划项目 （）
