中国药业2016，Vol.25Issue(20)：29-32,4.
欧芹根总黄酮对非酒精性脂肪性肝病大鼠的治疗作用及机制研究
Curative Effect and Mechanism of Total Flavonoids in Roots of Petroselinum Crispum on Nonalcoholic Fatty Liver Rat Model
摘要
Abstract
Objective To explore the effect mechanism of total flavonoids in roots of petroselinum crispum on nonalcoholic fatty liver rat model. Methods 40 cases of nonalcoholic fatty liver rat model were induced by high-fat diet and then randomly divided into the nor-mal group,model group,silymarin group and total flavonoids in roots of petroselinum crispum group,10 rats in each group. All group were given the corresponding treatment. Except for the normal group,the other groups were fed with high-fat diet. The plasma level of ALT,AST,TG,TC were detected and the expression of COX-2 mRNA in liver was examined by Quantitative Real-time PCR. Results The model was made successfully,and the plasma level of ALT,AST,TG,TC in model groups were higher than that in normal group. After intervention,the NAFLD rats with silymarin and total flavonoids in roots of petroselinum crispum decresed the above-men-tioned four indexes obviously,and the expression of COX-2 mRNA was inhibited( P < 0. 05). The effects of total flavonoids in roots of petroselinum crispum were stronger than silymarin,but the differences were not statistically significant( P > 0. 05). Conclusion The to-tal flavonoids in roots of petroselinum crispum has a specific curative effect on NAFLD rats. Its mechanism is related to the inhibition of COX-2 mRNA expression.关键词
欧芹根总黄酮/非酒精性脂肪性肝病/环氧合酶-2Key words
total flavonoids in roots of petroselinum crispum/nonalcoholic fatty liver disease/COX-2分类
医药卫生引用本文复制引用
谢婧雯,陈妍,贾蔓菁,朱曼丽,雷林杰..欧芹根总黄酮对非酒精性脂肪性肝病大鼠的治疗作用及机制研究[J].中国药业,2016,25(20):29-32,4.基金项目
新疆医科大学科研创新基金，项目编号XJC201359。 （）
