摘要
Abstract
Objective To investigate the effect of febuxostat on the inflammatory state and the function of vascular endothelial cells in the treatment of gout with hyperuricemia. Methods 60 cases of gout with hyperuricemia from June 2013 to December 2014 were se-lected and randomly divided into the control group and the observation group, 30 cases in each group. The control group received 300 mg of allopurinol oral treatment, 100 mg/times, tid; the observation group received 80 mg of febuxostat oral treatment, 80 mg/times, qd. Treatment period of both groups lasted for 24 weeks. The clinical symptoms and signs were observed, the treatment effect was evalu-ated, the levels of serum interleukin 1 β ( IL-1β) , interleukin 6 ( IL-6 ) serum tumor necrosis factor-α ( TNF-α) and endothelin-1 ( ET-1 ) before and after treatment in the two groups were detected, and the incidence of adverse reactions were recorded. Results Af-ter treatment, There was no significant difference between the two groups in the total effective rate ( P > 0. 05 );the levels of IL-1β, IL-6 and TNF-α in the two groups were significantly lower than those before treatment ( P < 0. 05 ) , and the decrease of IL-1βand IL-6 in the observation group was more significant ( P < 0. 05 ) , with no statistically significant difference of TNF-α between the two groups ( P > 0. 05 );the levels of ET-1 in the two groups were significantly lower than those before, and the decrease in the observa-tion group was more significant ( P < 0. 05 ) . The adverse reactions in the two groups were all transient, and there was no significant dif-ference in the incidence rate of adverse reactions between the two groups during the treatment ( P > 0. 05 ) . Conclusion Febuxostat in the treatment of gout with hyperuricemia can effectively decrease the hyperuricemia, inhibit the expression of inflammatory factors and improve the function of vascular endothelial cells. The adverse reactions are less and the safety is higher.关键词
非布司他/别嘌呤醇/痛风/高尿酸血症/炎症状态/内皮细胞功能Key words
febuxostat/allopurinol/gout/hyperuricemia/inflammatory state/endothelial cell function分类
医药卫生
