分析化学2016，Vol.44Issue(12)：1859-1866,8.DOI:10.11895/j.issn.0253-3820.160451
基于金属有机框架结构的分子印迹聚合物电化学传感器检测猪尿中苯乙醇胺A
Molecularly Imprinting Polymer Electrochemical Sensor Based on Structure of Metal Organic Frameworks for Determination of Phenylethanolamine A in Swine Urine
摘要
Abstract
A supersensitive molecular imprinting polymer ( MIP ) electrochemical sensor based on the structure of metal organic frameworks ( MOFs) for detection of phenylethanolamine A ( PEA) in swine urine samples was developed. In this sensor, PEA was used as template, p-aminothiophenol was selected as functional monomer and organic ligand, and Au nanoparticles were used as metal center to fabricate a composite membrane with molecular recognition property on gold electrode by in situ electrochemical polymerization. The characterizations of modified electrode were performed with electrochemical platform and scanning electronic microscope. The analytical conditions including scan rate, pH, elution time and incubation time and so on were optimized. Under the optimum conditions, the limit of the developed MOFs-MIP electrochemical sensor for the detection for PEA was as low as 1 . 0í10-13 mol/L and the linear rang was from 1 . 0í10-13 to 1 . 0í10-9 mol/L with correlation coefficient of 0 . 996 . The recoveries of PEA were from 92 . 7% to 108 . 4% under different spiked levels of PEA in animal urine and the relative standard deviation (RSD) was below 8. 0%. The developed method possessed many advantages such as high sensitivity, specificity and stability.关键词
苯乙醇胺A/分子印迹聚合物/金属有机框架/电化学传感器Key words
Phenylethanolamine A/Molecular imprinting polymer/Metal organic frameworks/Electrochemical sensor引用本文复制引用
张春艳,王培龙,石雷,苏晓鸥..基于金属有机框架结构的分子印迹聚合物电化学传感器检测猪尿中苯乙醇胺A[J].分析化学,2016,44(12):1859-1866,8.基金项目
本文系国家自然科学基金(No.21576128)和农业专项科研基金(No.201203088)资助项目 （No.21576128）
