广西师范大学学报（自然科学版）2016，Vol.34Issue(3)：102-108,7.DOI:10.16088/j.issn.1001-6600.2016.03.014
1,8-萘二甲酰亚胺衍生物NA-17对肝癌细胞株H epG2的体外抗肿瘤作用研究
The Anti-Tumor Mechanism of 1,8-Naphthalate Formyl Imide Derivative NA-1 7 in HepG2 Cells
摘要
Abstract
The antitumor effects of a novel 1 ,8-naphthalate formyl imide derivative NA-1 7 in human liver cancer cells was researched.The inhibition effects of NA-1 7 in various human cancer cell lines showed that NA-17 exhibited highly selective inhibition in human liver cancer cell line HepG2,but with low toxicity to normal hepatic cell HL-7702.Preliminary research indicated that NA-17 induced apoptosis to suppress proliferation in HepG2 cells.Further studies showed that NA-17 induced the increase in the levels of Bak,while the decrease in Bcl-2 and Bcl-xL to trigger cell apoptosis.关键词
NA-17/细胞凋亡/HepG2/选择性抑制/抗肿瘤活性Key words
NA-17/apoptosis/HepG2/selective inhibition/antineoplastic activity引用本文复制引用
吴亦明,李亮萍,曾淑兰,李晓红,周祖平,彭艳..1,8-萘二甲酰亚胺衍生物NA-17对肝癌细胞株H epG2的体外抗肿瘤作用研究[J].广西师范大学学报（自然科学版）,2016,34(3):102-108,7.基金项目
广西自然科学基金资助项目(2014GXNSFAA118165,2015GXNSFDA139010) （2014GXNSFAA118165,2015GXNSFDA139010）
教育部创新团队项目(IRT1225) （IRT1225）
广西医药产业人才小高地资助项目(1309,1312,1507) （1309,1312,1507）
药用资源化学与药物分子工程省部共建国家重点实验室主任基金资助项目(CMEMR2015-A09,CMEMR2014-A11) （CMEMR2015-A09,CMEMR2014-A11）
广西研究生教育创新计划项目(JGY2015023) （JGY2015023）
八桂学者计划资助项目 （）
