常州大学学报（自然科学版）2016，Vol.28Issue(6)：23-27,5.DOI:10.3969/j.issn.2095-0411.2016.06.005
人参二醇的微生物转化及抗HSC-T6细胞活性研究
Microbial Transformation of 20 (R)-Panaxadiol and Their Activity Against HSC-T6 Cells
摘要
Abstract
To investigate the derivatives of 20(R)-panaxadiol and their activities against HSC-T6 cells,20 (R)-panaxadiol was treated by Mucorspinosus AS 3.3450.All products were isolated by silica gel chroma-tography and purified by preparative HPLC.On the basis of spectral data,structures were elucidated.The activity against HSC-T6 cells was measured by MTT method.Five biotransformation products were ob-tained and identified as 3-oxo-20 (R)-panaxadiol (1),3-oxo-7β,24α-dihydroyl-20 (R)-panaxadiol (2),3-oxo-7β,24β-dihydroyl-20 (R)-panaxadiol (3),3-oxo-15α,24α-dihydroyl-20 (R)-panaxadiol (4),3-oxo-15α,24β-dihydroyl-20 (R)-panaxadiol (5).MTT assay revealed that compounds 1-3 showed higher in-hibitory activity against HSC-T6 cells than 20(R)-panaxadiol.关键词
人参二醇/微生物转化/HSC-T6细胞/抗肝纤维化Key words
20(R)-panaxadiol/microbial transformation/HSC-T6/anti-liver fibrotic分类
医药卫生引用本文复制引用
朱梦月,雷静,周垚,戴秋阳,朱腊梅,陈广通..人参二醇的微生物转化及抗HSC-T6细胞活性研究[J].常州大学学报（自然科学版）,2016,28(6):23-27,5.基金项目
江苏省高等学校大学生创新创业训练计划项目(201610304075Y) （201610304075Y）
南通市科技项目(MS12015044). （MS12015044）
