摘要
Abstract
Objective To explore the changes and clinical value of serum Golgi protein (GP)73 level in chronic HBV patient . Methods Three‐hundred chronic HBV patients from January 2013 to June 2015 in hospital were enrolled in this study and divided into four group based on clinical status :HBV‐C group(n=50) ,CHB group(n=120) ,LC group(n=60) and HCC group(n=70) . The levels of GP73 in each group were compared by using correlation analysis and ROC curve analysis .Results The levels of GP 73 in HBV‐C group were significantly lower than those in CHB group ,HCC group and LC group[(117 .3 ± 12 .8) ng/mL ,(181 .5 ± 21 .7) ng/mL ,(263 .2 ± 33 .4) ng/mL vs .(39 .2 ± 3 .5) ng/mL ,P<0 .05] .The contents of CHB group were significantly lower than those in HCC group and LC group[(181 .5 ± 21 .7)ng/mL ,(263 .2 ± 33 .4)ng/mL vs .(117 .3 ± 12 .8) ng/mL ,P<0 .05] .The patients with compensatory LC had a lower serum GP 73 compared with de‐compensatory patients [(245 .6 ± 29 .3)ng/mL vs . (279 .5 ± 39 .6)ng/mL ,P<0 .05] .Correlation analysis showed that serum GP73 were positively associated with AST (r= 0 .554 , P<0 .05) ,ALT(r=0 .409 ,P<0 .05) ,albumin(r=0 .445 ,P<0 .05) ,Child‐pugh grade(r=0 .609 ,P<0 .05) and de‐compensatory LC(r=0 .722 ,P<0 .05) .ROC analysis suggested that AUC of GP73 for CHB was 0 .741 ,95% CI:0 .519-0 .813 ,cut off value was 176 .3 ng/mL ,the sensitivity was 77 .8% ,specificity was 77 .2% ;AUC of GP73 for HCC was 0 .749 ,95% CI:0 .676 -0 .834 ,cut off value was 232 .0 ng/mL ,the sensitivity was 78 .0% ,specificity was 82 .5% ;AUC of GP73 for LC was 0 .738 ,95% CI:0 .636 -0 .841 ,cut off value was 292 .2 ng/mL ,the sensitivity was 74 .4% ,specificity was 80 .9% .AUC of GP73 for the loss of compensa‐tory LC was 0 .802 ,95% CI:for the 0 .699-0 .932 ,off cut value was 319 .3 ng/mL ,the sensitivity was 84 .2% ,the specificity was 90 .3% .Conclusion GP73 can be used as a sensitive and specific liver marker ,not only to help early diagnosis of HCC and LC ,but also help to judge the state of liver function in patients with LC .关键词
乙型肝炎/血清高尔基蛋白73/临床意义Key words
hepatitis B/serum Golgi protein 73/clinical value
