摘要
Abstract
Objective To investigate the curative efficacy of intensity modulated radiation therapy in combination with oxalipla‐tin+capecitabine(XELOX) program in patients with advanced esophageal cancer .Methods Totally 120 patients of advanced e‐sophageal cancer who received therapy in our hospital from January 2012 to December 2013 were collected as research objects and divided into the control group(n=60) and the observation group(n=60) .The control group was given intensity modulated radia‐tion therapy .Besides that ,the observation group was given XELOX program additionally .Then ,the short‐term ,long‐term curative efficacy ,levels of serum vascular endothelial growth factor (VEGF) and toxic side effects between the two groups were compared . Results After the course of treatment ,the short‐term curative efficacy ratio in the observation group was 81 .7% ,which was statis‐tically higher than that of 63 .3% in the control group(P<0 .05) .As to long‐term curative efficacy ,the one‐year survival rate and two‐year survival rate in the observation group was statistically higher than the control group respectively (66 .7% vs .48 .3% , 50 .0% vs .31 .7% ,both P<0 .05) .After the treatments ,level of serum VEGF in the observation group was statistically lower than that in the control group[(401 .2 ± 50 .4) ng/L vs .(457 .8 ± 54 .9) ng/L ,P<0 .05] .During the treatments ,the incidences ofⅠ - Ⅱdegree ,Ⅲ - Ⅳ degree of radiation esophagitis ,radiation pneumonitis ,gastrointestinal reaction and myelosuppression in the two groups had no statistical significance(P> 0 .05) .Conclusion Intensity modulated radiation therapy in combination with XELOX program is effective for advanced esophageal cancer ,which can significantly increase short‐term ,long‐term curative efficacy and re‐duce level of serum VEGF without increasing incidence of toxic side effects .关键词
适形调强放疗/XELOX同步化疗/晚期食管癌/血管内皮生长因子Key words
intensity modulated radiation therapy/XELOX program/advanced esophageal cancer/vascular endothelial grow th factor
