摘要
Abstract
Objective To observe the clinical efficacy and safety of sensipar in the treatment of secondary parathyroid function ( SHPT) in hemodialysis patients .Methods 98 cases of SHPT patients after hemodialysis in the Department of Nephrology Hubei Huangshi Aikang Hospital from March 2013 to December 2015 and were selected , according to single blind digital random method , the cases were divided into study group ( sensipar combined with calcitriol pulse therapy , 49 cases ) and control group (standard calcitriol pulse therapy, 49 cases), the clinical efficacy, laboratory indexes and adverse reactions after 3 months treatment were compared and analyzed in two months .Results The total efficiency of observation group was 95.92%(47/49), which was higher than that of the control group 81.64% (40/49) (χ2 =5.018, P =0.25); after 3 months of treatment,control group's serum calcium was (2.29 ±0.26) mmol/L, calcium and phosphorus product was (45.98 ±6.27) mg/dl,observation group's serum calcium was (2.61 ±0.27) mmol/L, calcium and phosphorus product was (47.65 ±6.41) mg/dl,the observation group was significantly higher than that of control group ( t =2.786, t =6.178, P <0.05);intact parathyroid hormone (iPTH) was (129.45 ±25.87) pg/ml, blood phosphorus (1.03+0.06) mmol/L in the control group, intact parathyroid hormone (iPTH) was (307.25 ±36.45) pg/ml, blood phosphorus (1.65 ±0.08) mmol/L, the observation group was significantly lower than the control group ( t =10.986, P =0.000;t =3.015, P =0.034); the 2 groups after treatment, parathyroid gland volume was significantly reduced , and the observation group (59.97 ±6.41) mm3 was significantly less than the control group (129.37 ±8.58) mm3 ( t =19.846, P =0.000); observation group's adverse reactions of drugs was 4.08%(2/49), which was lower than that of the control group's 18.37%(9/49) (χ2 =5.018, P =0 .025).Conclusion Sensipar assisted treatment of hemodialysis SHPT can promote the iPTH and reduce the size of the par -athyroid gland , less adverse reactions , it is worthy of clinical promotion .关键词
血液透析/继发性甲状旁腺功能亢进/全段甲状旁腺激素/西那卡塞Key words
Hemodialysis/Secondary hyperparathyroidism/Parathyroid hormone/Sensipar
